IFNG and IFNGR1

Number of citations of the paper that reports this interaction (PMID 7673114)
21

Data Source:
BioGRID (x-ray crystallography, pull down)
HPRD (in vivo, in vitro)

		IFNG	IFNGR1
Gene Name		interferon, gamma	interferon gamma receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Dendrite Vesicle
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Neutrophil Apoptotic Process Regulation Of The Force Of Heart Contraction Positive Regulation Of Mesenchymal Cell Proliferation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Movement Of Cell Or Subcellular Component Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Neutrophil Chemotaxis Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Myelination Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Insulin Secretion Sensory Perception Of Mechanical Stimulus Positive Regulation Of Membrane Protein Ectodomain Proteolysis Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-18 Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Extrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Action Potential Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Regulation Of Hepatocyte Proliferation	Signal Transduction Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs		Olsalazine Glucosamine	Interferon gamma-1b
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228799 21297633 19122664)
Protein-Protein Interactions		5 interactors: IFNGR1 IFNGR2 PDIA3 STAT6 TNF	10 interactors: CANX IFNG IFNGR2 JAK1 JAK2 PTPN11 RAC1 SOCS1 STAT1 STAT4
Entrez ID		3458	3459
HPRD ID		00957	00127
Ensembl ID		ENSG00000111537	ENSG00000027697
Uniprot IDs		P01579	B4DFT7 F5H5M7 P15260
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES	1FG9 1FYH 1JRH
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Immune Response Response To Virus Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Regulation Of Immune System Process Defense Response Response To Stress Epithelial Cell Proliferation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Protein Import Into Nucleus Negative Regulation Of Immune Response Response To Other Organism Nuclear Import Interferon-gamma-mediated Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Innate Immune Response Cellular Response To Interferon-gamma T-helper 1 Cell Lineage Commitment Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Gland Morphogenesis Protein Import Response To Interferon-gamma Protein Localization To Nucleus Signal Transduction Response To Organic Substance Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Cell Communication	Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Response To Interferon-gamma Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Innate Immune Response Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Type I Interferon-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process JAK-STAT Cascade Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Type I Interferon Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Response To Growth Hormone Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Signaling Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of JAK-STAT Cascade Cellular Response To Peptide Response To Stress Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Migration Cell Motility
Tagcloud ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	30min ancestry asks asleep habitual il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender