IFI16 and ID2

Number of citations of the paper that reports this interaction (PMID 11940648)
13

Data Source:
HPRD (in vivo, in vitro)

		IFI16	ID2
Gene Name		interferon, gamma-inducible protein 16	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Cytoskeleton Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding Poly(A) RNA Binding	Protein Binding Ion Channel Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Transcription, DNA-templated Autophagy Inflammatory Response Cell Proliferation Regulation Of Autophagy Hemopoiesis Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Natural Killer Cell Differentiation Membranous Septum Morphogenesis Bundle Of His Development Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Celiac disease and Rheumatoid arthritis ( 21383967) Obesity-related traits ( 23251661)	IgE levels ( 22075330)
Protein-Protein Interactions		10 interactors: APP AR BRCA1 CSNK2A1 ID1 ID2 ID3 TP53 TP53BP1 TPR	37 interactors: ADD1 ASB4 CDK2 ELK1 ELK3 ELK4 GATA4 HES1 HSPA5 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 PAX2 PAX5 PAX8 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TSTA3 UNC119
Entrez ID		3428	3398
HPRD ID		00969	02664
Ensembl ID		ENSG00000163565	ENSG00000115738
Uniprot IDs		Q16666	Q02363 Q53T66
PDB IDs		2OQ0 3B6Y 3RLN 3RLO 3RNU	4AYA
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle RNA Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Regulation Of Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Ossification Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Chromosome Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Muscle Structure Development Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Differentiation Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Organ Development Positive Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Cell Fate Commitment Developmental Process Regulation Of Cellular Process Chromatin Modification Tissue Development Skeletal Muscle Tissue Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Development
Tagcloud ?		bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53	basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion
Tagcloud (Difference) ?		bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53	basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion
Tagcloud (Intersection) ?