IFI16

Gene Name		interferon, gamma-inducible protein 16
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Transcription, DNA-templated Autophagy Inflammatory Response Cell Proliferation Regulation Of Autophagy Hemopoiesis Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Celiac disease and Rheumatoid arthritis ( 21383967) Obesity-related traits ( 23251661)
Protein-protein Interactions		10 interactors: APP AR BRCA1 CSNK2A1 ID1 ID2 ID3 TP53 TP53BP1 TPR
Entrez ID		3428
HPRD ID		00969
Ensembl ID		ENSG00000163565
Uniprot IDs		Q16666
PDB IDs		2OQ0 3B6Y 3RLN 3RLO 3RNU
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle RNA Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Regulation Of Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Ossification Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Chromosome Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?		bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53