IDE and NES

Number of citations of the paper that reports this interaction (PMID 21185309)
6

Data Source:
BioGRID (pull down)

		IDE	NES
Gene Name		insulin-degrading enzyme	nestin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Cell Surface Cytosolic Proteasome Complex	Cytoplasm Intermediate Filament Intermediate Filament Cytoskeleton
	Molecular Function	Beta-amyloid Binding Glycoprotein Binding Metalloendopeptidase Activity Receptor Binding Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Ubiquitin Binding Insulin Binding	Molecular_function Structural Molecule Activity Intermediate Filament Binding
	Biological Process	Proteolysis Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Homeostasis Viral Process Positive Regulation Of Protein Oligomerization Hormone Catabolic Process Negative Regulation Of Proteolysis Beta-amyloid Metabolic Process Protein Homooligomerization Protein Homotetramerization Protein Heterooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Insulin Metabolic Process Insulin Catabolic Process	G2/M Transition Of Mitotic Cell Cycle Central Nervous System Development Brain Development Positive Regulation Of Intermediate Filament Depolymerization Embryonic Camera-type Eye Development Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Cell Projection Morphogenesis Stem Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs		Insulin Regular Insulin, porcine Bacitracin
Diseases
GWAS		Airflow obstruction ( 22837378) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		10 interactors: APP AR IGF1 IGF2 INS NES NR3C1 PEX5 UBC UCHL5	4 interactors: CDK1 CDK5 CDK5R1 IDE
Entrez ID		3416	10763
HPRD ID		00894	09020
Ensembl ID		ENSG00000119912	ENSG00000132688
Uniprot IDs		P14735	P48681 Q9H6U9
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSE 4GSF 4IOF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Glucose Metabolic Process Organ Development Positive Regulation Of Mitotic Cell Cycle Regulation Of Glycogen Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Cycle Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction System Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Platelet Degranulation Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Multicellular Organismal Development Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Protein Oligomerization Exocrine Pancreas Development Regulation Of Multicellular Organism Growth Pancreas Development Negative Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Glycolytic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Developmental Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity	Peptidyl-threonine Phosphorylation Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Negative Regulation Of Axon Extension Regulation Of Developmental Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Transport Layer Formation In Cerebral Cortex Axon Guidance Cerebral Cortex Radial Glia Guided Migration Regulation Of Dendritic Spine Development Regulation Of Intracellular Transport Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Axonogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Axon Extension Positive Regulation Of Transferase Activity Regulation Of Dendrite Morphogenesis Hippocampus Development Axon Development Positive Regulation Of Neuron Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Growth Regulation Of Protein Transport Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Limbic System Development Regulation Of Cell Cycle Arrest Regulation Of Neurogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation
Tagcloud ?		affects analogues autocrine clearly degrading des igfs inducer isoforms metalloendopeptidase neuroblastoma neuroblastomas neuroectodermal paracrine participate peptidases physiologically posttranslational programmed proteolytic rars retinoic retinoid rxr rxrs since start thermolysin tme	autoinhibitory bipartite carries cytoplasm exclusively export exportin gfp hydrophobic import keywords leptomycin leucine mapkap mimicry mk2 nls overlapping redistribution rev sb203580 spacing supposed t317 t317a translocates translocation unexpectedly unlike
Tagcloud (Difference) ?		affects analogues autocrine clearly degrading des igfs inducer isoforms metalloendopeptidase neuroblastoma neuroblastomas neuroectodermal paracrine participate peptidases physiologically posttranslational programmed proteolytic rars retinoic retinoid rxr rxrs since start thermolysin tme	autoinhibitory bipartite carries cytoplasm exclusively export exportin gfp hydrophobic import keywords leptomycin leucine mapkap mimicry mk2 nls overlapping redistribution rev sb203580 spacing supposed t317 t317a translocates translocation unexpectedly unlike
Tagcloud (Intersection) ?