IDE

Gene Name		insulin-degrading enzyme
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Cell Surface Cytosolic Proteasome Complex
	Molecular Function	Beta-amyloid Binding Glycoprotein Binding Metalloendopeptidase Activity Receptor Binding Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Ubiquitin Binding Insulin Binding
	Biological Process	Proteolysis Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Homeostasis Viral Process Positive Regulation Of Protein Oligomerization Hormone Catabolic Process Negative Regulation Of Proteolysis Beta-amyloid Metabolic Process Protein Homooligomerization Protein Homotetramerization Protein Heterooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Insulin Metabolic Process Insulin Catabolic Process
Pathways
Drugs		Insulin Regular Insulin, porcine Bacitracin
Diseases
GWAS		Airflow obstruction ( 22837378) Type 2 diabetes ( 20581827)
Protein-protein Interactions		10 interactors: APP AR IGF1 IGF2 INS NES NR3C1 PEX5 UBC UCHL5
Entrez ID		3416
HPRD ID		00894
Ensembl ID		ENSG00000119912
Uniprot IDs		P14735
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSE 4GSF 4IOF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Glucose Metabolic Process Organ Development Positive Regulation Of Mitotic Cell Cycle Regulation Of Glycogen Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Cycle Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction System Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Platelet Degranulation Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Multicellular Organismal Development Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Protein Oligomerization Exocrine Pancreas Development Regulation Of Multicellular Organism Growth Pancreas Development Negative Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Glycolytic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Developmental Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?		affects analogues autocrine clearly degrading des igfs inducer isoforms metalloendopeptidase neuroblastoma neuroblastomas neuroectodermal paracrine participate peptidases physiologically posttranslational programmed proteolytic rars retinoic retinoid rxr rxrs since start thermolysin tme