HSPE1 and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPE1	UNC119
Gene Name		heat shock 10kDa protein 1	unc-119 homolog (C. elegans)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane Extracellular Vesicular Exosome	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding	Protein Binding Lipid Binding
	Biological Process	Osteoblast Differentiation Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ALDH2 APLP1 C14orf1 CASP3 CRMP1 EEF1A1 GBP2 HSPD1 LRIF1 SAT1 STK3 TLE1 UNC119 ZHX1	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		3336	9094
HPRD ID		02535	04927
Ensembl ID		ENSG00000115541	ENSG00000109103
Uniprot IDs		P61604	Q13432
PDB IDs			3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hippo Signaling Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Clathrin-mediated Endocytosis B Cell Cytokine Production Isotype Switching To IgG Isotypes Cellular Response To Stimulus Execution Phase Of Apoptosis Response To Stimulus Nitrogen Compound Metabolic Process Spermidine Acetylation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Caveolin-mediated Endocytosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Stabilization Signaling Activation Of Cysteine-type Endopeptidase Activity Anatomical Structure Morphogenesis Cell Communication Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Putrescine Catabolic Process Zymogen Activation Apoptotic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Oxalate Transport Regulation Of Protein Stability Regulation Of Nitrogen Compound Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Regulation Of Neurotransmitter Levels Positive Regulation Of Cellular Protein Metabolic Process Response To Xenobiotic Stimulus Positive Regulation Of Peptidase Activity Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Response To Norepinephrine Regulation Of Cellular Protein Metabolic Process Regulation Of Caveolin-mediated Endocytosis Glial Cell Apoptotic Process	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
Tagcloud ?		antimicrobials cdkn1a chelation dnaja1 epiderm exquisite gstm3 hmox1 hspa1a hspa1l hspa6 hspb5 hspd1 hsph1 icp inductively investigational metallothionein microbicidal mt2a pyrithione reconstructed reconstructs sod2 topical toxicological upregulates vanicream znpt
Tagcloud (Difference) ?		antimicrobials cdkn1a chelation dnaja1 epiderm exquisite gstm3 hmox1 hspa1a hspa1l hspa6 hspb5 hspd1 hsph1 icp inductively investigational metallothionein microbicidal mt2a pyrithione reconstructed reconstructs sod2 topical toxicological upregulates vanicream znpt
Tagcloud (Intersection) ?