HSPE1 and SAT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		HSPE1	SAT1
Gene Name		heat shock 10kDa protein 1	spermidine/spermine N1-acetyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane Extracellular Vesicular Exosome	Intracellular Cytosol
	Molecular Function	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding	Diamine N-acetyltransferase Activity Protein Binding Spermidine Binding
	Biological Process	Osteoblast Differentiation Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein	Angiogenesis Polyamine Metabolic Process Polyamine Biosynthetic Process Putrescine Catabolic Process Spermidine Acetylation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Small Molecule Metabolic Process
Pathways			Metabolism of polyamines Interconversion of polyamines Metabolism of amino acids and derivatives
Drugs			N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ALDH2 APLP1 C14orf1 CASP3 CRMP1 EEF1A1 GBP2 HSPD1 LRIF1 SAT1 STK3 TLE1 UNC119 ZHX1	75 interactors: ABCB8 APLP1 B4GALT3 C14orf1 C19orf25 CASP7 CCDC148 CCDC90B CCHCR1 CHD3 COPS6 CRMP1 CSNK2A1 CSNK2A2 DDX39A DGKZ DMRT3 DNPEP EEF1G EIF3D EPHB6 EVA1A FAM156A FAM69B FAM86C1 FTSJ3 FUNDC2 GBP2 GDF9 GNB2L1 HIF1A HOXB6 HOXB9 HSPE1 INO80C ITGA9 JUNB KAT5 KAT7 KCNA4 KIAA1377 LNX1 LRIF1 LUC7L2 MED31 MRPL9 MTA1 NIF3L1 NMRK2 PLGRKT PRDX2 PTN RBM17 RBM48 REL RELA RPLP1 SARAF SAT2 SEPHS1 SETDB1 SNAI2 TACO1 TCF25 TLE1 TP53 TP53TG1 TSC22D4 TUBB2A UBE2D3 UNC119 UTP14A VASP VKORC1 ZHX1
Entrez ID		3336	6303
HPRD ID		02535	02431
Ensembl ID		ENSG00000115541	ENSG00000130066
Uniprot IDs		P61604	P21673 Q6ICU9
PDB IDs			2B3U 2B3V 2B4B 2B4D 2B58 2B5G 2F5I 2FXF 2G3T 2JEV
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hippo Signaling Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Clathrin-mediated Endocytosis B Cell Cytokine Production Isotype Switching To IgG Isotypes Cellular Response To Stimulus Execution Phase Of Apoptosis Response To Stimulus Nitrogen Compound Metabolic Process Spermidine Acetylation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Caveolin-mediated Endocytosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Stabilization Signaling Activation Of Cysteine-type Endopeptidase Activity Anatomical Structure Morphogenesis Cell Communication Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Putrescine Catabolic Process Zymogen Activation Apoptotic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Oxalate Transport Regulation Of Protein Stability Regulation Of Nitrogen Compound Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Regulation Of Neurotransmitter Levels Positive Regulation Of Cellular Protein Metabolic Process Response To Xenobiotic Stimulus Positive Regulation Of Peptidase Activity Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Response To Norepinephrine Regulation Of Cellular Protein Metabolic Process Regulation Of Caveolin-mediated Endocytosis Glial Cell Apoptotic Process	RNA Metabolic Process Gene Expression RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Response To External Stimulus Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Locomotion Regulation Of Interleukin-12 Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Response To Ionizing Radiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Axon Guidance Response To Abiotic Stimulus
Tagcloud ?		antimicrobials cdkn1a chelation dnaja1 epiderm exquisite gstm3 hmox1 hspa1a hspa1l hspa6 hspb5 hspd1 hsph1 icp inductively investigational metallothionein microbicidal mt2a pyrithione reconstructed reconstructs sod2 topical toxicological upregulates vanicream znpt	acetyltransferase biologic catabolism chemoradiation databases dr dramatic explaining gbm glioblastoma ionizing lies mechanistically multiforme n1 neurosphere oncomine polyamine radiation radioresistance radiosensitization recombination referenced rembrandt sensitization sensitize shrna spermidine spermine
Tagcloud (Difference) ?		antimicrobials cdkn1a chelation dnaja1 epiderm exquisite gstm3 hmox1 hspa1a hspa1l hspa6 hspb5 hspd1 hsph1 icp inductively investigational metallothionein microbicidal mt2a pyrithione reconstructed reconstructs sod2 topical toxicological upregulates vanicream znpt	acetyltransferase biologic catabolism chemoradiation databases dr dramatic explaining gbm glioblastoma ionizing lies mechanistically multiforme n1 neurosphere oncomine polyamine radiation radioresistance radiosensitization recombination referenced rembrandt sensitization sensitize shrna spermidine spermine
Tagcloud (Intersection) ?