AGFG1 and RNF216

Number of citations of the paper that reports this interaction (PMID 11854271)
6

Data Source:
HPRD (in vivo)

		AGFG1	RNF216
Gene Name		ArfGAP with FG repeats 1	ring finger protein 216
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Cytoplasmic Membrane-bounded Vesicle Cell Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Acrosome Assembly MRNA Export From Nucleus Multicellular Organismal Development Spermatid Nucleus Differentiation Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Intermediate Filament Organization	Apoptotic Process Viral Process Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APC APP EPS15 EPS15L1 ITSN1 NYAP2 PKIA POLE2 RNF216 VAMP7 XPO1	11 interactors: AGFG1 BRCA1 KIR2DL4 RIPK1 RNF11 TLR3 TLR4 TLR5 TLR9 UBE2L3 UBE2L6
Entrez ID		3267	54476
HPRD ID		02918	15550
Ensembl ID		ENSG00000173744	ENSG00000011275
Uniprot IDs		P52594	A8K8N1 Q9NWF9
PDB IDs		2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Neuron Projection Morphogenesis Regulation Of Intracellular Protein Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Regulation Of Protein Localization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Protein Targeting To Vacuolar Membrane Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Signal Transduction Neuron Development Apoptotic Process Post-Golgi Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Localization Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Negative Regulation Of Signal Transduction Establishment Of Localization In Cell Neuron Differentiation Cell Surface Receptor Signaling Pathway Cell Projection Organization Ribosomal Small Subunit Export From Nucleus Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Collateral Sprouting In Absence Of Injury Triglyceride Transport Negative Regulation Of Signaling Axonogenesis Regulation Of Microtubule Cytoskeleton Organization Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity	Positive Regulation Of Interleukin-8 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Cellular Response To Organic Substance Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Defense Response Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of JNK Cascade Regulation Of Interferon-beta Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Chemokine Production Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Chemokine Production Response To Organic Substance I-kappaB Kinase/NF-kappaB Signaling Necroptotic Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity
Tagcloud ?			amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations
Tagcloud (Difference) ?			amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations
Tagcloud (Intersection) ?