AIRE and DAXX

Number of citations of the paper that reports this interaction (PMID 20185822)
5

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		AIRE	DAXX
Gene Name		autoimmune regulator	death-domain associated protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Chromosome, Centromeric Region Heterochromatin Nucleus Nucleolus Cytoplasm Cytosol PML Body SWI/SNF Superfamily-type Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Translation Regulator Activity	P53 Binding Transcription Corepressor Activity Receptor Signaling Protein Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 21505073)
Protein-Protein Interactions		5 interactors: CREBBP DAXX HIST1H3A HIST2H2BE UBAC1	82 interactors: AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP DAPK3 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3F3A HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HIST1H3C HIST1H4F HIST4H4 HSF1 HSPB1 MAP3K5 MCRS1 MDM2 MST1 MX1 MYH11 NECAB2 NR3C1 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PRMT1 RASSF1 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STUB1 SUMO1 TCF3 TCF7L2 TGFB1 TGFB2 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBE2I USP7 WHSC1L1
Entrez ID		326	1616
HPRD ID		06301	04424
Ensembl ID		ENSG00000160224	ENSG00000204209
Uniprot IDs		O43918	B4E1C1 F5ANJ6 F5ANJ7 Q53F85 Q9UER7
PDB IDs		1XWH 2KE1 2KFT 2LRI	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Chromatin Organization DNA Packaging DNA Conformation Change Chromosome Organization Protein Complex Assembly Cellular Macromolecular Complex Assembly Cellular Component Assembly N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Germ-line Stem Cell Maintenance Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Response To Stress N-terminal Protein Amino Acid Acetylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Innate Immune Response In Mucosa Regulation Of Gene Silencing Viral Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Antibacterial Humoral Response N-terminal Protein Amino Acid Modification Antimicrobial Humoral Response Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Cellular Response To Heat Mucosal Immune Response Chromatin Silencing Activation Of JUN Kinase Activity Androgen Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Mitotic Cytokinesis Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress DNA Methylation	Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cell Death Regulation Of Signal Transduction Death Apoptotic Process Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Signaling Transcription, DNA-templated Cellular Response To Stress Cellular Aromatic Compound Metabolic Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Response To Stimulus Chromosome Organization Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
Tagcloud ?		adhere alive apcs behave confluency crosstalk dead differentiating fate fractionated fresh implied kill killer mdcs medullary mimic mtec mtecs named pass reproducing rescuer surprisingly tec1 tec2 thymic thymocytes tsas	adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?		adhere alive apcs behave confluency crosstalk dead differentiating fate fractionated fresh implied kill killer mdcs medullary mimic mtec mtecs named pass reproducing rescuer surprisingly tec1 tec2 thymic thymocytes tsas	adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?