AIRE

Gene Name		autoimmune regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Translation Regulator Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 21505073)
Protein-protein Interactions		5 interactors: CREBBP DAXX HIST1H3A HIST2H2BE UBAC1
Entrez ID		326
HPRD ID		06301
Ensembl ID		ENSG00000160224
Uniprot IDs		O43918
PDB IDs		1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Chromatin Organization DNA Packaging DNA Conformation Change Chromosome Organization Protein Complex Assembly Cellular Macromolecular Complex Assembly Cellular Component Assembly N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Germ-line Stem Cell Maintenance Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Response To Stress N-terminal Protein Amino Acid Acetylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Innate Immune Response In Mucosa Regulation Of Gene Silencing Viral Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Antibacterial Humoral Response N-terminal Protein Amino Acid Modification Antimicrobial Humoral Response Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Cellular Response To Heat Mucosal Immune Response Chromatin Silencing Activation Of JUN Kinase Activity Androgen Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Mitotic Cytokinesis Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress DNA Methylation
Tagcloud ?		adhere alive apcs behave confluency crosstalk dead differentiating fate fractionated fresh implied kill killer mdcs medullary mimic mtec mtecs named pass reproducing rescuer surprisingly tec1 tec2 thymic thymocytes tsas