HPRT1 and PRTFDC1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		HPRT1	PRTFDC1
Gene Name		hypoxanthine phosphoribosyltransferase 1	phosphoribosyl transferase domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Guanine Phosphoribosyltransferase Activity	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Homodimerization Activity
	Biological Process	Response To Amphetamine Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Cytolysis Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Small Molecule Metabolic Process Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process	Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage GMP Salvage IMP Salvage GMP Catabolic Process Hypoxanthine Metabolic Process
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage
Drugs		Azathioprine Mercaptopurine Alpha-Phosphoribosylpyrophosphoric Acid Pyrophosphate 2- 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol 9-Deazaguanine
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: FANCA ISCU PRTFDC1 SDCBP WDYHV1	12 interactors: DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B MCMBP NIF3L1 STAT5A TCL1A
Entrez ID		3251	56952
HPRD ID		02388	17917
Ensembl ID		ENSG00000165704	ENSG00000099256
Uniprot IDs		P00492	Q9NRG1
PDB IDs		1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6	2JBH
Enriched GO Terms of Interacting Partners?		Nitrogen Fixation Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly	Positive Regulation Of Mast Cell Differentiation GMP Salvage GMP Catabolic Process Guanine Salvage Glucosamine Catabolic Process FAD Biosynthetic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Mast Cell Differentiation Adenine Salvage Dihydrobiopterin Metabolic Process Hypoxanthine Salvage Development Of Secondary Male Sexual Characteristics Positive Regulation Of Dopamine Metabolic Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mast Cell Apoptotic Process GMP Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Creatinine Metabolic Process Regulation Of Mast Cell Apoptotic Process Purine Nucleoside Monophosphate Catabolic Process Glucosamine Metabolic Process Positive Regulation Of Mast Cell Proliferation Riboflavin Metabolic Process Isoleucine Metabolic Process Allantoin Metabolic Process Purine Ribonucleoside Salvage Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Organonitrogen Compound Heterocycle Metabolic Process Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway GMP Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Glycogen (starch) Synthase Activity Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Purine Ribonucleoside Catabolic Process Luteinization Positive Regulation Of Glycogen Biosynthetic Process
Tagcloud ?		cloning eif2 eif3 exerts gels gtp hershey homologue migrates migrating multisubunit p110 p116 p170 p35 p40 p44 p47 p48 p66 polyacrylamide raised recognizes ribosome sds stabilizes ternary trna
Tagcloud (Difference) ?		cloning eif2 eif3 exerts gels gtp hershey homologue migrates migrating multisubunit p110 p116 p170 p35 p40 p44 p47 p48 p66 polyacrylamide raised recognizes ribosome sds stabilizes ternary trna
Tagcloud (Intersection) ?