HOXA5 and FOXA2

Number of citations of the paper that reports this interaction (PMID 12642491)
13

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		HOXA5	FOXA2
Gene Name		homeobox A5	forkhead box A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Respiratory System Process Transcription, DNA-templated Anterior/posterior Pattern Specification Positive Regulation Of Receptor Biosynthetic Process Cell Migration Negative Regulation Of Angiogenesis Thyroid Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Embryonic Skeletal System Morphogenesis Bronchiole Development Epithelial Tube Branching Involved In Lung Morphogenesis Lung Goblet Cell Differentiation Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Intestinal Epithelial Cell Maturation Mesenchymal-epithelial Cell Signaling Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cell-cell Signaling Involved In Mammary Gland Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose In Utero Embryonic Development Ectoderm Formation Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Adult Locomotory Behavior Negative Regulation Of Epithelial To Mesenchymal Transition Chromatin Modification Regulation Of Steroid Metabolic Process Cell Differentiation In Hindbrain Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Blood Coagulation Endocrine Pancreas Development Somite Rostral/caudal Axis Specification Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Development Neuron Fate Specification Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Connective Tissue Development Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways			Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 20152958) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		11 interactors: CDX4 DDIT3 FOXA2 FOXO1 GTF2A1L MEIS1 PBX1 PRMT6 SMAD1 TWIST1 ZNF408	9 interactors: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		3202	3170
HPRD ID		00840	02618
Ensembl ID		ENSG00000106004	ENSG00000125798
Uniprot IDs		P20719	B0ZTD4 Q9Y261
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Cardiovascular System Development Pattern Specification Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Blood Vessel Development Vasculature Development Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Ossification Skeletal System Development System Development Embryo Development Cellular Metabolic Process	Organ Development Positive Regulation Of Gene Expression System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Hindbrain Development Embryonic Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Embryonic Morphogenesis Developmental Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Endoderm Development Embryonic Organ Morphogenesis Brain Development Chordate Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Embryo Development Ending In Birth Or Egg Hatching Head Development Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Metencephalon Development Central Nervous System Development Somite Rostral/caudal Axis Specification Cell Development Forebrain Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Epithelium Development RNA Metabolic Process Embryonic Skeletal System Development Embryo Development Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Gastrulation
Tagcloud ?		aberrant abilities abstract arrests committed depending drives erythrocyte erythroid erythropoiesis expanding g0 hsc hscs inappropriate lineage modifies mpps multipotency multipotent pool predominance preferentially progenitor progenitors renewal seq shrinks sustain	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Difference) ?		aberrant abilities abstract arrests committed depending drives erythrocyte erythroid erythropoiesis expanding g0 hsc hscs inappropriate lineage modifies mpps multipotency multipotent pool predominance preferentially progenitor progenitors renewal seq shrinks sustain	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Intersection) ?