HOXA5 and CDX4

Number of citations of the paper that reports this interaction (PMID 15684390)
8

Data Source:
HPRD (in vitro, in vivo)

		HOXA5	CDX4
Gene Name		homeobox A5	caudal type homeobox 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Respiratory System Process Transcription, DNA-templated Anterior/posterior Pattern Specification Positive Regulation Of Receptor Biosynthetic Process Cell Migration Negative Regulation Of Angiogenesis Thyroid Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Embryonic Skeletal System Morphogenesis Bronchiole Development Epithelial Tube Branching Involved In Lung Morphogenesis Lung Goblet Cell Differentiation Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Intestinal Epithelial Cell Maturation Mesenchymal-epithelial Cell Signaling Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cell-cell Signaling Involved In Mammary Gland Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Transcription, DNA-templated Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CDX4 DDIT3 FOXA2 FOXO1 GTF2A1L MEIS1 PBX1 PRMT6 SMAD1 TWIST1 ZNF408	7 interactors: CKS1B HOXA5 LMO1 LMO2 PITX1 PRKAA1 PRKAB2
Entrez ID		3202	1046
HPRD ID		00840	02065
Ensembl ID		ENSG00000106004
Uniprot IDs		P20719	O14627
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Cardiovascular System Development Pattern Specification Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Blood Vessel Development Vasculature Development Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Ossification Skeletal System Development System Development Embryo Development Cellular Metabolic Process	Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Gene Expression Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Negative Regulation Of Glucose Import In Response To Insulin Stimulus Cell-cell Signaling Involved In Mammary Gland Development Branchiomeric Skeletal Muscle Development Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Camptothecin Bronchiole Development Lung Goblet Cell Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Kinase Activity Cartilage Development Intestinal Epithelial Cell Maturation Transcription From RNA Polymerase II Promoter Cellular Response To Insulin Stimulus Negative Regulation Of Sphingolipid Biosynthetic Process Lobar Bronchus Development Myoblast Fate Commitment Regulation Of Cell Cycle Response To Hormone Connective Tissue Development Regulation Of Ceramide Biosynthetic Process Transcription, DNA-templated Carnitine Shuttle Positive Regulation Of Cholesterol Biosynthetic Process Cell Cycle Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Ethanol Bronchus Development Trachea Cartilage Morphogenesis Regulation Of Protein Phosphorylation RNA Biosynthetic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		aberrant abilities abstract arrests committed depending drives erythrocyte erythroid erythropoiesis expanding g0 hsc hscs inappropriate lineage modifies mpps multipotency multipotent pool predominance preferentially progenitor progenitors renewal seq shrinks sustain	alters auto caudal chip circuit coregulate deeper defects erythroid erythropoiesis explain facilitates hematopoiesis hox initiate insight lmo2 locus mesoderm posterior proceeds profiling program rescued sall4 seq spalt zebrafish
Tagcloud (Difference) ?		aberrant abilities abstract arrests committed depending drives erythrocyte expanding g0 hsc hscs inappropriate lineage modifies mpps multipotency multipotent pool predominance preferentially progenitor progenitors renewal shrinks sustain	alters auto caudal chip circuit coregulate deeper defects explain facilitates hematopoiesis hox initiate insight lmo2 locus mesoderm posterior proceeds profiling program rescued sall4 spalt zebrafish
Tagcloud (Intersection) ?		erythroid erythropoiesis seq