HMGCL and ADAMTS10

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HMGCL	ADAMTS10
Gene Name		3-hydroxymethyl-3-methylglutaryl-CoA lyase	ADAM metallopeptidase with thrombospondin type 1 motif, 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Peroxisome	Microfibril Extracellular Matrix
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Receptor Binding Manganese Ion Binding Carboxylic Acid Binding Protein Homodimerization Activity Metal Ion Binding	Molecular_function Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Liver Development Leucine Catabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Ketone Body Metabolic Process Ketone Body Biosynthetic Process Protein Tetramerization Response To Fatty Acid	Proteolysis Biological_process
Pathways		Ketone body metabolism Fatty acid, triacylglycerol, and ketone body metabolism Synthesis of Ketone Bodies Metabolism of lipids and lipoproteins	Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS			Height ( 20881960 18391951)
Protein-Protein Interactions		8 interactors: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 MS4A7 PEX5 RNF126	7 interactors: ANXA7 CDKN1A HMGCL LAMTOR3 PCYT2 SMN1 TK1
Entrez ID		3155	81794
HPRD ID		02003	07470
Ensembl ID		ENSG00000117305	ENSG00000142303
Uniprot IDs		B1AK13 P35914	M0QZE4 Q59FE5 Q6ZN14 Q9H324
PDB IDs		2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?		Protein Targeting Cellular Localization Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Cellular Protein Localization Protein Localization To Organelle Intracellular Transport Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Protein Homotetramerization Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Protein Import Into Peroxisome Matrix, Translocation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Protein Import Protein Targeting To Membrane Protein Import Into Peroxisome Matrix, Docking Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Protein Localization Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Establishment Of Localization In Cell Negative Regulation Of Protein Homooligomerization Cell Motility Intracellular Protein Transport Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Comma-shaped Body Morphogenesis Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Membrane Common Bile Duct Development Protein To Membrane Docking Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development DNA Damage Response, Detection Of DNA Damage Peroxisomal Membrane Transport S-shaped Body Morphogenesis Negative Regulation Of Hematopoietic Progenitor Cell Differentiation	Response To Organic Substance Response To Extracellular Stimulus Fetal Process Involved In Parturition Protein Tetramerization Skeletal Muscle Cell Proliferation Digestive Tract Development Digestive System Development Liver Development Response To Glucocorticoid Response To Corticosteroid Response To Toxic Substance Leucine Catabolic Process Intestinal Epithelial Cell Maturation Response To Lipid Response To Organic Cyclic Compound Response To Cortisol Thymidine Metabolic Process Cellular Response To UV-B Deoxyribonucleoside Monophosphate Biosynthetic Process Ketone Body Biosynthetic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Leucine Metabolic Process Cellular Ketone Body Metabolic Process Stress-induced Premature Senescence Response To Metal Ion Phosphatidylethanolamine Biosynthetic Process Cellular Water Homeostasis Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development Anatomical Structure Development Parturition Regulation Of Protein Import Into Nucleus, Translocation Branched-chain Amino Acid Catabolic Process Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Positive Regulation Of TOR Signaling Response To Nutrient Levels Protein Oligomerization Response To Copper Ion Response To Inorganic Substance Response To Steroid Hormone Response To Arsenic-containing Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Gland Development
Tagcloud ?			adjuvant antitumor cdna cultured doses exert facilitate fold foundation hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt
Tagcloud (Difference) ?			adjuvant antitumor cdna cultured doses exert facilitate fold foundation hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt
Tagcloud (Intersection) ?