HMGCL and MS4A7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HMGCL	MS4A7
Gene Name		3-hydroxymethyl-3-methylglutaryl-CoA lyase	membrane-spanning 4-domains, subfamily A, member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Peroxisome	Integral Component Of Membrane
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Receptor Binding Manganese Ion Binding Carboxylic Acid Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Liver Development Leucine Catabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Ketone Body Metabolic Process Ketone Body Biosynthetic Process Protein Tetramerization Response To Fatty Acid
Pathways		Ketone body metabolism Fatty acid, triacylglycerol, and ketone body metabolism Synthesis of Ketone Bodies Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 MS4A7 PEX5 RNF126	2 interactors: HMGCL SLC35F6
Entrez ID		3155	58475
HPRD ID		02003	07579
Ensembl ID		ENSG00000117305	ENSG00000166927
Uniprot IDs		B1AK13 P35914	Q9GZW8
PDB IDs		2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?		Protein Targeting Cellular Localization Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Cellular Protein Localization Protein Localization To Organelle Intracellular Transport Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Protein Homotetramerization Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Protein Import Into Peroxisome Matrix, Translocation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Protein Import Protein Targeting To Membrane Protein Import Into Peroxisome Matrix, Docking Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Protein Localization Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Establishment Of Localization In Cell Negative Regulation Of Protein Homooligomerization Cell Motility Intracellular Protein Transport Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Comma-shaped Body Morphogenesis Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Membrane Common Bile Duct Development Protein To Membrane Docking Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development DNA Damage Response, Detection Of DNA Damage Peroxisomal Membrane Transport S-shaped Body Morphogenesis Negative Regulation Of Hematopoietic Progenitor Cell Differentiation	Leucine Catabolic Process Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Ketone Body Biosynthetic Process Leucine Metabolic Process Cellular Ketone Body Metabolic Process Branched-chain Amino Acid Catabolic Process Negative Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Acyl-CoA Metabolic Process Response To Fatty Acid
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