HLA-C and TAP2

Number of citations of the paper that reports this interaction (PMID 9551969)
24

Data Source:
HPRD (in vivo)

		HLA-C	TAP2
Gene Name		major histocompatibility complex, class I, C	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane TAP Complex
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP Binding	Transporter Activity Protein Binding ATP Binding Peptide Transporter Activity Peptide Antigen-transporting ATPase Activity MHC Class Ib Protein Binding TAP1 Binding Tapasin Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Metabolic Process Intracellular Transport Of Viral Protein In Host Cell Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Peptide Antigen Transport Transmembrane Transport
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Atopic dermatitis ( 23042114) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233) Height ( 23563607) HIV-1 control ( 21051598 20041166) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145) Protein quantitative trait loci ( 18464913) Psoriasis ( 20953188 20953190 18369459 18364390 19169254) Psoriatic arthritis ( 20953186) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Vitiligo ( 20526339) White blood cell count ( 21738480)	Lymphoma ( 23349640) Nephropathy ( 21399633) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		20 interactors: B2M BATF2 CALR CD8A CDC25A CXCR4 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 PRRG4 TANK TAP2 TAPBP YBX1	9 interactors: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP
Entrez ID		3107	6891
HPRD ID		00829	01360
Ensembl ID		ENSG00000204525	ENSG00000204267
Uniprot IDs		O19617 P10321 Q6R739 Q95HC2	Q03519 Q9UP03
PDB IDs		3BZF
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Defense Response Response To Biotic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Response To Stress Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell Activation Response To Other Organism Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Response To Stimulus Leukocyte Activation Antigen Processing And Presentation Of Endogenous Antigen Single Organismal Cell-cell Adhesion Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Innate Immune Response Response To External Stimulus Immune Response-regulating Signaling Pathway Dendritic Cell Differentiation Negative Regulation Of Calcium Ion Transport Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Interferon-beta Secretion Peptide Antigen Stabilization Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Signal Transduction	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Viral Process Immune Response Defense Response Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Innate Immune Response Positive Regulation Of Cell Cycle Response To Stress Positive Regulation Of Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of T Cell Mediated Cytotoxicity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Cytokine-mediated Signaling Pathway Positive Regulation Of Ligase Activity Regulation Of T Cell Mediated Cytotoxicity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Peptide Antigen Stabilization Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			beta2 blocker chains clamp class confocal detectable dissociated drastically electric electrophysiological electrophysiology exceptions heavy ifn mhc microglobulin neurons neurotransmitter partly patch reverted tap1 tetrodotoxin transcribe transcribed transporters upregulate
Tagcloud (Difference) ?			beta2 blocker chains clamp class confocal detectable dissociated drastically electric electrophysiological electrophysiology exceptions heavy ifn mhc microglobulin neurons neurotransmitter partly patch reverted tap1 tetrodotoxin transcribe transcribed transporters upregulate
Tagcloud (Intersection) ?