HLA-C and KIR2DL2

Number of citations of the paper that reports this interaction (PMID 10190900)
85

Data Source:
HPRD (in vitro)

		HLA-C	KIR2DL2
Gene Name		major histocompatibility complex, class I, C	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Regulation Of Immune Response
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Atopic dermatitis ( 23042114) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233) Height ( 23563607) HIV-1 control ( 21051598 20041166) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145) Protein quantitative trait loci ( 18464913) Psoriasis ( 20953188 20953190 18369459 18364390 19169254) Psoriatic arthritis ( 20953186) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		20 interactors: B2M BATF2 CALR CD8A CDC25A CXCR4 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 PRRG4 TANK TAP2 TAPBP YBX1	2 interactors: CD93 HLA-C
Entrez ID		3107	3803
HPRD ID		00829	16080
Ensembl ID		ENSG00000204525
Uniprot IDs		O19617 P10321 Q6R739 Q95HC2	P43627 Q6H2H0 Q8N742
PDB IDs		3BZF	1EFX 2DL2 2DLI
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Defense Response Response To Biotic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Response To Stress Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell Activation Response To Other Organism Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Response To Stimulus Leukocyte Activation Antigen Processing And Presentation Of Endogenous Antigen Single Organismal Cell-cell Adhesion Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Innate Immune Response Response To External Stimulus Immune Response-regulating Signaling Pathway Dendritic Cell Differentiation Negative Regulation Of Calcium Ion Transport Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Interferon-beta Secretion Peptide Antigen Stabilization Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Signal Transduction	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Macrophage Activation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Immune System Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Response To Interferon-gamma Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Phagocytosis Antigen Processing And Presentation
Tagcloud ?			alleles analyse assigned c1 centromeric classical determination establish frequencies frequent genotype genotypes haplotypes hcv hla ifnl3 logic nsvr pegylated polymorphism powerful ppv predicting ribavirin rs12979860 sustained svr
Tagcloud (Difference) ?			alleles analyse assigned c1 centromeric classical determination establish frequencies frequent genotype genotypes haplotypes hcv hla ifnl3 logic nsvr pegylated polymorphism powerful ppv predicting ribavirin rs12979860 sustained svr
Tagcloud (Intersection) ?