ACACA and CSNK2A2

Number of citations of the paper that reports this interaction (PMID 2900140)
12

Data Source:
HPRD (in vitro)

		ACACA	CSNK2A2
Gene Name		acetyl-CoA carboxylase alpha	casein kinase 2, alpha prime polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleus Cytosol PcG Protein Complex
	Molecular Function	Acetyl-CoA Carboxylase Activity Biotin Carboxylase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Carnitine Shuttle Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Multicellular Organismal Protein Metabolic Process Small Molecule Metabolic Process Protein Homotetramerization Lipid Homeostasis Malonyl-CoA Biosynthetic Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Import of palmitoyl-CoA into the mitochondrial matrix Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs		Biotin
Diseases
GWAS		Ovarian cancer ( 23535730)
Protein-Protein Interactions		9 interactors: ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 PRKAA1 PRKAA2 PRKAB1 PRKAG1	92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		31	1459
HPRD ID		01938	00279
Ensembl ID		ENSG00000132142	ENSG00000070770
Uniprot IDs		B2ZZ90 Q13085 Q7Z5W8	P19784
PDB IDs		2YL2 3COJ 4ASI	3E3B 3OFM 3U87
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Fatty Acid Biosynthetic Process Regulation Of Cell Cycle Cell Cycle Process Cell Cycle Fatty Acid Metabolic Process Regulation Of Glycolytic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Protein Phosphorylation Wnt Signaling Pathway Response To Insulin Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Chromosome Organization Response To Organonitrogen Compound Biosynthetic Process Regulation Of Gene Expression Response To Hormone Cellular Lipid Metabolic Process Phosphorylation Cellular Protein Modification Process Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process Carboxylic Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Peptide Hormone Fatty Acid Homeostasis Protein Heterooligomerization Positive Regulation Of Metabolic Process Regulation Of Lipid Biosynthetic Process Signaling Response To Peptide Cell Communication Organic Acid Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Lipid Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Glucose Starvation Regulation Of Chromosome Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Checkpoint	Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?