SERPIND1 and CTSG

Number of citations of the paper that reports this interaction (PMID 2318847)
8

Data Source:
HPRD (in vitro)

		SERPIND1	CTSG
Gene Name		serpin peptidase inhibitor, clade D (heparin cofactor), member 1	cathepsin G
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity
	Biological Process	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix
Drugs		Ardeparin Alpha-D-Mannose Sulodexide	Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP CTSG ELANE F2	28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		3053	1511
HPRD ID		00795	00289
Ensembl ID		ENSG00000099937	ENSG00000100448
Uniprot IDs		P05546 Q8IVC0	P08311
PDB IDs		1JMJ 1JMO	1AU8 1CGH 1KYN 1T32
Enriched GO Terms of Interacting Partners?		Killing By Host Of Symbiont Cells Regulation Of Growth Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Defense Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Extracellular Matrix Organization Extracellular Structure Organization Response To Fungus Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Acute Inflammatory Response Immune System Process Regulation Of Protein Metabolic Process Extracellular Matrix Disassembly Cellular Homeostasis Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Negative Regulation Of Protein Metabolic Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Synaptic Growth At Neuromuscular Junction Regulation Of Protein Phosphorylation Defense Response To Bacterium Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Leukocyte Migration Positive Regulation Of Protein Metabolic Process Locomotion Negative Regulation Of Growth Immune Response Regulation Of Phosphorylation Leukocyte Mediated Immunity Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Neurogenesis	Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility
Tagcloud ?			aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Difference) ?			aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Intersection) ?