CTSG and SELPLG

Number of citations of the paper that reports this interaction (PMID 11520793)
5

Data Source:
HPRD (in vivo)

		CTSG	SELPLG
Gene Name		cathepsin G	selectin P ligand
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity	Receptor Binding Protein Binding
	Biological Process	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium	Cell Adhesion Blood Coagulation Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix	Cell surface interactions at the vascular wall
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS			Conduct disorder (symptom count) ( 20585324)
Protein-Protein Interactions		28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	13 interactors: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		1511	6404
HPRD ID		00289	02845
Ensembl ID		ENSG00000100448	ENSG00000110876
Uniprot IDs		P08311	Q14242
PDB IDs		1AU8 1CGH 1KYN 1T32	1G1S
Enriched GO Terms of Interacting Partners?		Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility	Leukocyte Migration Peptidyl-tyrosine Sulfation Leukocyte Cell-cell Adhesion Cell Adhesion Regulation Of Immune System Process Inflammatory Response Cell Migration Protein Sulfation Cell Motility Single Organismal Cell-cell Adhesion Leukocyte Tethering Or Rolling Sulfation Locomotion Regulation Of Leukocyte Migration Defense Response Immune System Process Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Positive Regulation Of Immune System Process Response To Bacterium Cellular Extravasation Regulation Of Platelet Activation Defense Response To Bacterium Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Body Fluid Levels Response To Fungus Wound Healing Response To Wounding Response To Other Organism Response To Biotic Stimulus Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Lipopolysaccharide Platelet Degranulation Response To Molecule Of Bacterial Origin Sulfur Compound Metabolic Process Regulation Of Immune Response Response To Stress Positive Regulation Of Leukocyte Migration Glycoprotein Biosynthetic Process Cellular Response To Molecule Of Fungal Origin Neutrophil Mediated Killing Of Gram-positive Bacterium Beta Selection Selenium Compound Metabolic Process Positive Regulation Of Interleukin-3 Biosynthetic Process Regulation Of Blood Coagulation Glycoprotein Metabolic Process Serotonin Secretion By Platelet Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Prevention Of Polyspermy
Tagcloud ?		aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram	aggregates allele angioplasty atherothrombosis carrier carriers depended glycoprotein ile62 inducible irrespective leukocyte lpa monocyte mpa npa pivotal platelet pp pro715 psgl selectin sp stenting stronger thrombin trap variations
Tagcloud (Difference) ?		aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram	aggregates allele angioplasty atherothrombosis carrier carriers depended glycoprotein ile62 inducible irrespective leukocyte lpa monocyte mpa npa pivotal platelet pp pro715 psgl selectin sp stenting stronger thrombin trap variations
Tagcloud (Intersection) ?