ANXA1 and S100A11

Number of citations of the paper that reports this interaction (PMID 8557678)
9

Data Source:
HPRD (in vivo, in vitro)

		ANXA1	S100A11
Gene Name		annexin A1	S100 calcium binding protein A11
Image
Gene Ontology Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome	Ruffle Extracellular Space Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding
	Biological Process	DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion	Signal Transduction Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs		Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS		Schizophrenia, bipolar disorder and depression (combined) ( 20713499)
Protein-Protein Interactions		31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ	4 interactors: ACTB ANXA1 NCL S100B
Entrez ID		301	6282
HPRD ID		01060	04385
Ensembl ID		ENSG00000135046	ENSG00000163191
Uniprot IDs		P04083 Q5TZZ9	P31949
PDB IDs		1AIN 1BO9 1QLS	1V4Z 1V50 2LUC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Neutrophil Clearance Response To Glucocorticoid Response To Corticosteroid DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Phospholipase A2 Activity Gliogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Interleukin-8 Secretion Defense Response Prolactin Secretion Positive Regulation Of Prostaglandin Biosynthetic Process System Development Negative Regulation Of Phospholipase Activity Homotypic Cell-cell Adhesion Neurogenesis Positive Regulation Of Myeloid Cell Apoptotic Process Response To Methylmercury Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Phospholipase A2 Activity Anatomical Structure Development DNA Strand Renaturation Arachidonic Acid Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Response To Steroid Hormone Negative Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Secretion Neutrophil Homeostasis Hepatocyte Differentiation Immune System Process Single Organismal Cell-cell Adhesion Axonogenesis Developmental Process Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Transcription From RNA Polymerase I Promoter Axon Development Negative Regulation Of Lipase Activity Nervous System Development Negative Regulation Of Skeletal Muscle Tissue Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Vesicle Fusion Positive Regulation Of Programmed Cell Death Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Death Anatomical Structure Morphogenesis Positive Regulation Of Cell Cycle G1/S Phase Transition Neuron Projection Morphogenesis
Tagcloud ?		aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	a2 abstract accumulates annexin annexins ca2 constant cytoskeleton damaged depending ef entry environment harsh imposed initiates injured metastatic motility organelles partner pm pmr repair respond stresses stroma
Tagcloud (Difference) ?		aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	a2 abstract accumulates annexin annexins ca2 constant cytoskeleton damaged depending ef entry environment harsh imposed initiates injured metastatic motility organelles partner pm pmr repair respond stresses stroma
Tagcloud (Intersection) ?