SERTAD1 and HSPB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SERTAD1	HSPB1
Gene Name		SERTA domain containing 1	heat shock 27kDa protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Ubiquitin Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated	Retina Homeostasis Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Movement Of Cell Or Subcellular Component Response To Unfolded Protein Response To Virus Gene Expression Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements Signaling by VEGF AUF1 (hnRNP D0) destabilizes mRNA VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ASB8 ATXN7L3 CCND2 CDK4 CDKN2A CHURC1 CIB3 COPB1 CREBBP DENND4A EGLN3 EP300 FAH HIVEP1 HSPB1 KAT2B KLHL42 MVP P4HA3 PATE1 POT1 PRDM4 RBX1 RCHY1 ROPN1 SETD7 SFI1 SMAD3 SPEN STAT5B SUPT7L TCEB1 TGM2 TLR4 TRIM28 ZNF410	40 interactors: ACTC1 AKT1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX EFTUD2 EIF4G1 HNRNPD HSPB8 IGSF21 INS LBP LRIF1 MAPKAPK2 MAPKAPK3 MAPKAPK5 MED31 MFAP1 NFKBIA PLG POP7 PPA1 PPM1A PRKD1 PRPF19 RBM48 RPS6KA5 SERTAD1 SF3B3 SMARCD1 SNCA TGFB1I1 TGM1 TP53 UCHL5 WDR83
Entrez ID		29950	3315
HPRD ID		15326	09076
Ensembl ID			ENSG00000106211
Uniprot IDs		Q53GC0 Q9UHV2	P04792
PDB IDs			3Q9P 3Q9Q
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Response To Hypoxia Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Oxygen Levels N-terminal Protein Amino Acid Acetylation Viral Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Notch Signaling Pathway Negative Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Protein Metabolic Process Chromatin Organization Chromosome Organization Positive Regulation Of Interleukin-1 Production N-terminal Protein Amino Acid Modification Positive Regulation Of Cytokine Production Response To Abiotic Stimulus	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of Transport Positive Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Peptidyl-serine Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Reactive Oxygen Species Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intracellular Transport MyD88-dependent Toll-like Receptor Signaling Pathway Gene Expression
Tagcloud ?			adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Difference) ?			adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Intersection) ?