HSPB1 and PRPF19

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		HSPB1	PRPF19
Gene Name		heat shock 27kDa protein 1	pre-mRNA processing factor 19
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Vesicular Exosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Particle Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Ubiquitin Binding Poly(A) RNA Binding	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Retina Homeostasis Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Movement Of Cell Or Subcellular Component Response To Unfolded Protein Response To Virus Gene Expression Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining RNA Splicing Lipid Biosynthetic Process Gene Expression Proteasomal Protein Catabolic Process Cellular Protein Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Signaling by VEGF AUF1 (hnRNP D0) destabilizes mRNA VEGFA-VEGFR2 Pathway	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTC1 AKT1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX EFTUD2 EIF4G1 HNRNPD HSPB8 IGSF21 INS LBP LRIF1 MAPKAPK2 MAPKAPK3 MAPKAPK5 MED31 MFAP1 NFKBIA PLG POP7 PPA1 PPM1A PRKD1 PRPF19 RBM48 RPS6KA5 SERTAD1 SF3B3 SMARCD1 SNCA TGFB1I1 TGM1 TP53 UCHL5 WDR83	17 interactors: BCAS2 CDC5L DDX42 DNTT EGLN3 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA1 RPA2 RPA3 U2AF1 UBE2D3
Entrez ID		3315	27339
HPRD ID		09076	12214
Ensembl ID		ENSG00000106211	ENSG00000110107
Uniprot IDs		P04792	Q9UMS4
PDB IDs		3Q9P 3Q9Q	4LG8
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of Transport Positive Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Peptidyl-serine Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Reactive Oxygen Species Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intracellular Transport MyD88-dependent Toll-like Receptor Signaling Pathway Gene Expression	DNA Recombinase Assembly Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleotide-excision Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Repair RNA Splicing Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Mismatch Repair Base-excision Repair Cellular Response To Heat Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition RNA Processing Cell Cycle Process DNA-dependent DNA Replication Response To Heat Heterocycle Metabolic Process Mitotic Cell Cycle Process DNA Catabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Double-strand Break Repair Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Protein-DNA Complex Assembly Response To Stress Cell Cycle
Tagcloud ?		adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?