GTF2B and ATF4

Number of citations of the paper that reports this interaction (PMID 9295363)
21

Data Source:
BioGRID (pull down)

		GTF2B	ATF4
Gene Name		general transcription factor IIB	activating transcription factor 4
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Dendrite Membrane Nuclear Periphery Neuron Projection Lewy Body Core ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Core Promoter Binding Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process	Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Amino Acid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome	ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		56 interactors: ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 MYC NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POLR2E POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE	65 interactors: APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CKAP4 CREB3 CREBZF DAPK3 DDIT3 DISC1 EGLN3 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA POLR2C PTCD3 REPS1 RPS6 SNAP29 SRA1 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226
Entrez ID		2959	468
HPRD ID		08928	06817
Ensembl ID		ENSG00000137947	ENSG00000128272
Uniprot IDs		Q00403	P18848 Q96AQ3
PDB IDs		1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG	1CI6
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression DNA-templated Transcription, Initiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Regulation Of Viral Transcription Response To Organic Substance Positive Regulation Of Viral Transcription Regulation Of Viral Process Cellular Response To Organic Substance Positive Regulation Of Viral Process Metabolic Process Steroid Hormone Mediated Signaling Pathway	Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Myeloid Cell Differentiation Leukocyte Differentiation Cellular Metabolic Process Response To Stress Apoptotic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Organ Development Myeloid Leukocyte Differentiation Defense Response Programmed Cell Death Immune System Process Response To Stimulus Cell Death Death Hemopoiesis Response To External Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?			activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?