GRM5 and PRKCD

Number of citations of the paper that reports this interaction (PMID 15894802)
16

Data Source:
HPRD (in vitro)

		GRM5	PRKCD
Gene Name		glutamate receptor, metabotropic 5	protein kinase C, delta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Astrocyte Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Glutamate Receptor Activity A2A Adenosine Receptor Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Insulin Receptor Substrate Binding Metal Ion Binding
	Biological Process	Activation Of MAPKKK Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Locomotory Behavior Negative Regulation Of Locomotion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Synaptic Transmission, Glutamatergic	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Gene Expression Regulation Of Receptor Activity Immunoglobulin Mediated Immune Response Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Binding Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Defense Response To Bacterium Negative Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Interferon gamma signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF Calmodulin induced events Regulation of mRNA stability by proteins that bind AU-rich elements Apoptotic cleavage of cellular proteins DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer Platelet activation, signaling and aggregation G alpha (q) signalling events HuR stabilizes mRNA DAG and IP3 signaling VEGFA-VEGFR2 Pathway CaM pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Signalling by NGF PLC beta mediated events Interferon Signaling Apoptotic execution phase Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling
Drugs		Acamprosate Rufinamide
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Tanning ( 19340012)	Bipolar disorder ( 21926972) Ulcerative colitis ( 23128233) Ventricular conduction ( 21076409)
Protein-Protein Interactions		19 interactors: CALM1 CALM2 CALM3 DYT10 EFNB2 FLNA GPRASP1 GRASP HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1	118 interactors: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 ADRBK1 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GNB2L1 GRM5 GSK3A HABP4 HDAC5 HIST1H1A HIST1H1B HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP VHL YWHAB YWHAG YWHAZ
Entrez ID		2915	5580
HPRD ID		04980	01501
Ensembl ID		ENSG00000168959	ENSG00000163932
Uniprot IDs		A8K5P7 P41594	Q05655
PDB IDs		3LMK	1YRK 2YUU
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Blood Coagulation Hemostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Phototransduction, Visible Light Signal Transduction Synaptic Transmission Cellular Response To Growth Factor Stimulus Activation Of Adenylate Cyclase Activity Cell-cell Signaling Response To Growth Factor Detection Of Visible Light Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Phototransduction Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Transport Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intracellular Signal Transduction Cell Communication	Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Cellular Response To Stimulus Cellular Response To Peptide Hormone Stimulus Defense Response Response To Stress Cellular Response To Organonitrogen Compound Response To Stimulus Platelet Activation Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Immune System Process Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Peptide Response To Hormone Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Innate Immune Response Regulation Of Signaling Response To Peptide Hormone Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Wound Healing Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Hemostasis Positive Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Modification Process Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Fc Receptor Signaling Pathway Immune Response Response To Insulin
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?