GRM5 and GRASP

Number of citations of the paper that reports this interaction (PMID 11850456)
30

Data Source:
HPRD (two hybrid, in vivo)

		GRM5	GRASP
Gene Name		glutamate receptor, metabotropic 5	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Astrocyte Projection	Cell Junction Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Coupled Receptor Activity Glutamate Receptor Activity A2A Adenosine Receptor Binding	PDZ Domain Binding ADP-ribosylation Factor Binding Identical Protein Binding
	Biological Process	Activation Of MAPKKK Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Locomotory Behavior Negative Regulation Of Locomotion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Synaptic Transmission, Glutamatergic	Signal Transduction Protein Localization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Acamprosate Rufinamide
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Tanning ( 19340012)
Protein-Protein Interactions		19 interactors: CALM1 CALM2 CALM3 DYT10 EFNB2 FLNA GPRASP1 GRASP HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1	7 interactors: CYTH3 DLG4 GABBR2 GRM1 GRM2 GRM3 GRM5
Entrez ID		2915	160622
HPRD ID		04980	17077
Ensembl ID		ENSG00000168959	ENSG00000161835
Uniprot IDs		A8K5P7 P41594	Q7Z6J2
PDB IDs		3LMK	2PNT
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Blood Coagulation Hemostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Phototransduction, Visible Light Signal Transduction Synaptic Transmission Cellular Response To Growth Factor Stimulus Activation Of Adenylate Cyclase Activity Cell-cell Signaling Response To Growth Factor Detection Of Visible Light Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Phototransduction Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Transport Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intracellular Signal Transduction Cell Communication	G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Nucleotide Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Locomotory Behavior Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Behavior Positive Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Learning G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Synaptic Plasticity Signaling Cell Communication Negative Regulation Of Catalytic Activity Cytosolic Calcium Ion Homeostasis Establishment Or Maintenance Of Cell Polarity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Negative Regulation Of Cellular Metabolic Process Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants
Tagcloud (Intersection) ?