GRIA4 and GRIA1

Number of citations of the paper that reports this interaction (PMID 9466455)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRIA4	GRIA1
Gene Name		glutamate receptor, ionotropic, AMPA 4	glutamate receptor, ionotropic, AMPA 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Junction Dendrite Endocytic Vesicle Membrane Vesicle Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome
	Molecular Function	Ionotropic Glutamate Receptor Activity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding Glutamate Receptor Activity PDZ Domain Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic	Signal Transduction Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Long Term Synaptic Depression
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses
Drugs		L-Glutamic Acid	L-Glutamic Acid Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Perampanel
Diseases
GWAS		Refractive error ( 23396134)	Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		12 interactors: ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	22 interactors: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1
Entrez ID		2893	2890
HPRD ID		00694	00695
Ensembl ID		ENSG00000152578	ENSG00000155511
Uniprot IDs		P48058 Q1WWK6	P42261 Q59GL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Activation Of Phospholipase C Activity Platelet Activation Protein Autophosphorylation Positive Regulation Of Phospholipase C Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Cell-cell Junction Assembly Cell Surface Receptor Signaling Pathway Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Long Term Synaptic Depression Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Nervous System Development Energy Reserve Metabolic Process Blood Coagulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Response To External Stimulus Positive Regulation Of Macrophage Differentiation Glutamate Receptor Signaling Pathway Protein Localization Cortical Actin Cytoskeleton Organization Positive Regulation Of Dense Core Granule Biogenesis Developmental Process Cortical Cytoskeleton Organization Cell Differentiation Nervous System Development Histone H3-T6 Phosphorylation Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Programmed Cell Death Neutrophil Chemotaxis Chemotaxis Anatomical Structure Development Apoptotic Signaling Pathway Receptor Clustering System Development Neutrophil Migration Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ion Transport Negative Regulation Of Cell Death Granulocyte Chemotaxis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Anatomical Structure Morphogenesis Intrinsic Apoptotic Signaling Pathway Cell Activation Regulation Of Cellular Localization Regulation Of Apoptotic Process Regulation Of Calcium Ion Transport Cellular Metal Ion Homeostasis Neuron-neuron Synaptic Transmission Regulation Of Signaling Signal Transduction Dendritic Spine Maintenance Response To Cytokine Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Death
Tagcloud ?		ae c3h chr directing discharges electroencephalographic frameshift gge handle harbors hej iap inbred mitigating modifier modifiers pcnxl2 profoundly retrotransposition retrotransposon seizing seizures spike substrain substrains surprising swd talen validating	acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Difference) ?		ae c3h chr directing discharges electroencephalographic frameshift gge handle harbors hej iap inbred mitigating modifier modifiers pcnxl2 profoundly retrotransposition retrotransposon seizing seizures spike substrain substrains surprising swd talen validating	acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Intersection) ?