GRIA1 and GRIPAP1

Number of citations of the paper that reports this interaction (PMID 10896157)
23

Data Source:
HPRD (in vivo)

		GRIA1	GRIPAP1
Gene Name		glutamate receptor, ionotropic, AMPA 1	GRIP1 associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome	Early Endosome Blood Microparticle
	Molecular Function	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding Glutamate Receptor Activity PDZ Domain Binding	Molecular_function
	Biological Process	Signal Transduction Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Long Term Synaptic Depression	Biological_process
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Perampanel
Diseases
GWAS		Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		22 interactors: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1	12 interactors: ARL15 CASP3 CCNT1 GRIA1 GRIP1 GRM7 RAB4A SMAD2 SMURF1 SPP1 TCEA2 TES
Entrez ID		2890	56850
HPRD ID		00695	02325
Ensembl ID		ENSG00000155511	ENSG00000068400
Uniprot IDs		P42261 Q59GL5	Q4V328
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Response To External Stimulus Positive Regulation Of Macrophage Differentiation Glutamate Receptor Signaling Pathway Protein Localization Cortical Actin Cytoskeleton Organization Positive Regulation Of Dense Core Granule Biogenesis Developmental Process Cortical Cytoskeleton Organization Cell Differentiation Nervous System Development Histone H3-T6 Phosphorylation Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Programmed Cell Death Neutrophil Chemotaxis Chemotaxis Anatomical Structure Development Apoptotic Signaling Pathway Receptor Clustering System Development Neutrophil Migration Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ion Transport Negative Regulation Of Cell Death Granulocyte Chemotaxis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Anatomical Structure Morphogenesis Intrinsic Apoptotic Signaling Pathway Cell Activation Regulation Of Cellular Localization Regulation Of Apoptotic Process Regulation Of Calcium Ion Transport Cellular Metal Ion Homeostasis Neuron-neuron Synaptic Transmission Regulation Of Signaling Signal Transduction Dendritic Spine Maintenance Response To Cytokine Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Death	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Stimulus Response To Transforming Growth Factor Beta Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signaling Regulation Of Cellular Process Cell Communication Glutamate Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Receptor Metabolic Process Regulation Of BMP Signaling Pathway Cell-cell Signaling DNA-templated Transcription, Elongation Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Protein Localization Memory Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Synaptic Transmission Positive Regulation Of Mesoderm Development Conditioned Taste Aversion Primary MiRNA Processing Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nodal Signaling Pathway Negative Regulation Of Collateral Sprouting Negative Regulation Of Glutamate Secretion Common-partner SMAD Protein Phosphorylation Glial Cell Apoptotic Process Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Apoptotic DNA Fragmentation
Tagcloud ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Difference) ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Intersection) ?