GRK6 and KCNIP3

Number of citations of the paper that reports this interaction (PMID 17102134)
14

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		GRK6	KCNIP3
Gene Name		G protein-coupled receptor kinase 6	Kv channel interacting protein 3, calsenilin
Image
Gene Ontology Annotations	Cellular Component	Membrane	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein C-terminus Binding Potassium Channel Regulator Activity Sequence-specific DNA Binding Ion Channel Binding Calcium-dependent Protein Binding
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Protein Transport Apoptotic Process Signal Transduction Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Regulation Of Neuron Apoptotic Process Behavioral Response To Pain Potassium Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	17 interactors: ADRBK1 CALM2 CASP3 CD177 CLN3 CREB1 CREM GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2
Entrez ID		2870	30818
HPRD ID		02925	05232
Ensembl ID		ENSG00000198055	ENSG00000115041
Uniprot IDs		P43250	Q9Y2W7
PDB IDs		2ACX 3NYN 3NYO	2E6W
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Negative Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Amyloid Precursor Protein Metabolic Process Regulation Of Protein Phosphorylation Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Phosphorylation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Activation Of Phospholipase C Activity Negative Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Regulation Of Kinase Activity Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Response To Stress Negative Regulation Of Kinase Activity Protein Processing Negative Regulation Of Apoptotic Process Positive Regulation Of Phospholipase Activity Negative Regulation Of Programmed Cell Death Learning Or Memory
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational
Tagcloud (Intersection) ?