GRK4 and FSHR

Number of citations of the paper that reports this interaction (PMID 10379886)
8

Data Source:
HPRD (in vitro)

		GRK4	FSHR
Gene Name		G protein-coupled receptor kinase 4	follicle stimulating hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell Cortex Dendrite Neuronal Cell Body	Plasma Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Follicle-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Internalization Termination Of G-protein Coupled Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Follicle-stimulating Hormone Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Menotropins Follitropin beta Urofollitropin Choriogonadotropin alfa Suramin
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Erectile dysfunction and prostate cancer treatment ( 20932654) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822)
Protein-Protein Interactions		5 interactors: BDKRB2 CALM1 FSHR IKBKG NEDD4	20 interactors: ADRBK1 AKT2 APPL1 ARR3 CANX CBX5 FSHB GRK4 GRK6 RNR2 RPS27A S100A10 TOP1 TOP1MT TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		2868	2492
HPRD ID		00656	00639
Ensembl ID		ENSG00000125388	ENSG00000170820
Uniprot IDs		P32298	F5GZW2 P23945
PDB IDs			1XUN 1XWD 4AY9
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Transmission Of Virus Development Involved In Symbiotic Interaction Response To Calcium Ion Regulation Of Protein Metabolic Process Cellular Response To Radiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Signal Transduction Intracellular Receptor Signaling Pathway Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Muscle Contraction Regulation Of Protein Phosphorylation Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Response To Abiotic Stimulus Follicle-stimulating Hormone Signaling Pathway Regulation Of High Voltage-gated Calcium Channel Activity G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Progesterone Receptor Signaling Pathway Muscle System Process Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Immune Response Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Phosphorylation Defense Response Glucocorticoid Receptor Signaling Pathway Regulation Of Response To Osmotic Stress Cellular Response To Stimulus Negative Regulation Of Protein Phosphorylation Response To Metal Ion Response To Light Stimulus Response To Stress	Glycogen Biosynthetic Process Viral Protein Processing Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Polysaccharide Metabolic Process Intracellular Transport Of Virus Regulation Of Cell Cycle Arrest Programmed Cell Death Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Death Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Rhythmic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Carbohydrate Biosynthetic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 2 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor 9 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Intersection) ?