FSHR and ARR3

Number of citations of the paper that reports this interaction (PMID 12850288)
4

Data Source:
HPRD (in vivo)

		FSHR	ARR3
Gene Name		follicle stimulating hormone receptor	arrestin 3, retinal (X-arrestin)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Synapse
	Molecular Function	Follicle-stimulating Hormone Receptor Activity Protein Binding	Opsin Binding Protein Binding Phosphoprotein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Follicle-stimulating Hormone Signaling Pathway	Regulation Of Protein Phosphorylation Endocytosis Signal Transduction Visual Perception
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Menotropins Follitropin beta Urofollitropin Choriogonadotropin alfa Suramin
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Erectile dysfunction and prostate cancer treatment ( 20932654) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822)
Protein-Protein Interactions		20 interactors: ADRBK1 AKT2 APPL1 ARR3 CANX CBX5 FSHB GRK4 GRK6 RNR2 RPS27A S100A10 TOP1 TOP1MT TUG1 UBA52 UBB UBC YWHAQ ZBTB16	23 interactors: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 CSNK2A2 CYTH1 DVL2 FSHR GNMT MAP2K7 OPN1MW OPN4 PARK2 PLK4 PTAFR PTGDS RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496
Entrez ID		2492	407
HPRD ID		00639	02358
Ensembl ID		ENSG00000170820	ENSG00000120500
Uniprot IDs		F5GZW2 P23945	P36575
PDB IDs		1XUN 1XWD 4AY9	1XEH 2A34
Enriched GO Terms of Interacting Partners?		Glycogen Biosynthetic Process Viral Protein Processing Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Polysaccharide Metabolic Process Intracellular Transport Of Virus Regulation Of Cell Cycle Arrest Programmed Cell Death Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Death Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Rhythmic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Carbohydrate Biosynthetic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 2 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor 9 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity	Protein-chromophore Linkage Regulation Of Carbohydrate Metabolic Process Response To External Stimulus Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Phototransduction, Visible Light Detection Of Visible Light Phototransduction Detection Of Light Stimulus Regulation Of Glucose Metabolic Process Regulation Of MAPK Cascade Response To Light Stimulus Positive Regulation Of Organelle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Rhodopsin Mediated Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Response To Abiotic Stimulus Cellular Metabolic Process Regulation Of JNK Cascade Bone Resorption G-protein Coupled Receptor Signaling Pathway Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Signaling Mitotic Spindle Checkpoint Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Chromosome Segregation Regulation Of Kinase Activity Cell Communication Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Lysosomal Transport Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Red, Far-red Light Phototransduction Regulation Of Cell Cycle Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Cellular Process
Tagcloud ?		ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr	arr2 arrestins arrs distributed gpcr gpcrs grk grk2 grk5 grk6 grks innate macrophages mechanistically modify responsiveness surprisingly talk tlr2 tlr3 tlr4 tlrs toll transcriptionally translational ubiquitously uncover vital
Tagcloud (Difference) ?		ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr	arr2 arrestins arrs distributed gpcr gpcrs grk grk2 grk5 grk6 grks innate macrophages mechanistically modify responsiveness surprisingly talk tlr2 tlr3 tlr4 tlrs toll transcriptionally translational ubiquitously uncover vital
Tagcloud (Intersection) ?