HEXDC and EEF1D

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HEXDC	EEF1D
Gene Name		hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Beta-N-acetylhexosaminidase Activity	DNA Binding Translation Elongation Factor Activity Signal Transducer Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding
	Biological Process	Carbohydrate Metabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Signal Transduction Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process
Pathways			Translation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ADPRHL2 C7orf25 EEF1D GDPD2 GLRX3 PARK2 PSD RILPL2 TUBB3	33 interactors: ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS ERP27 FOS FRA10AC1 GARS HEXDC KARS KTN1 MAP1B NR2F1 POT1 PRKCA RELA RPS6KA1 SIAH1 SIAH2 SQSTM1 TERF1 TINF2 TPT1 VARS
Entrez ID		284004	1936
HPRD ID		08677	00560
Ensembl ID		ENSG00000169660	ENSG00000104529
Uniprot IDs		Q8WVB3	B2RAR6 D3DWK1 P29692
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Negative Regulation Of Cardiac Muscle Hypertrophy Dopamine Transport Negative Regulation Of Muscle Hypertrophy Aggresome Assembly Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Zinc Ion Homeostasis Negative Regulation Of Release Of Cytochrome C From Mitochondria Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Ammonium Ion Cellular Response To Superoxide Regulation Of Dopamine Secretion Response To Oxidative Stress Cellular Response To Toxic Substance Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoamine Transport Mitochondrial Fission Cellular Response To Catecholamine Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Response To Superoxide Startle Response	Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Axonogenesis Regulation Of Telomere Maintenance Via Telomerase Axon Development Negative Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Toll-like Receptor 10 Signaling Pathway Cell Differentiation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Telomere Maintenance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Viral Genome Replication Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Schwann Cell Differentiation Neuron Projection Development Neurotrophin TRK Receptor Signaling Pathway Cell Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Axon Guidance Chemotaxis Neurotrophin Signaling Pathway Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Histone H4 Acetylation
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