GNA15 and TTC1

Number of citations of the paper that reports this interaction (PMID 12748287)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		GNA15	TTC1
Gene Name		guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	tetratricopeptide repeat domain 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Cytoplasm Peroxisomal Membrane
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway	Protein Folding
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS		Heart failure ( 20445134)
Protein-Protein Interactions		19 interactors: ADRB2 ADRBK1 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	17 interactors: ACY1 CRY2 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		2769	7265
HPRD ID		00760	11881
Ensembl ID		ENSG00000060558	ENSG00000113312
Uniprot IDs		P30679	Q99614
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Defense Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signaling Cell Communication Sensory Perception Of Pain Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Opioid Receptor Signaling Pathway Cellular Cation Homeostasis Cellular Response To Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Phosphorus Metabolic Process Cellular Chemical Homeostasis Blood Circulation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Muscle Contraction Response To Stress Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Cyclase Activity Immune Response Regulation Of Phosphorylation Cytosolic Calcium Ion Homeostasis Regulation Of MAPK Cascade Regulation Of Catalytic Activity Homeostatic Process Regulation Of Signaling Interleukin-8-mediated Signaling Pathway Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Muscle Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP Biosynthetic Process Negative Regulation Of Lyase Activity Response To Stimulus Regulation Of CAMP Metabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Catalytic Activity	Cellular Response To Stimulus Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Response To Organic Substance Wound Healing Positive Regulation Of Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stress Regulation Of Cell Differentiation Response To Wounding Blood Coagulation Platelet Activation Hemostasis Activation Of MAPKK Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Growth Generation Of Neurons Neurogenesis Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cell Growth Protein Refolding Regulation Of Catalytic Activity Response To Unfolded Protein Post-embryonic Development Locomotion Negative Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Cell Growth Regulation Of Cellular Response To Heat Regulation Of Myeloid Cell Differentiation Negative Regulation Of GTPase Activity Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Skeletal System Development Regulation Of Gene Expression Nervous System Development Activation Of Phospholipase C Activity Regulation Of Signaling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity
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