GNA15 and LTB4R

Number of citations of the paper that reports this interaction (PMID 9742207)
4

Data Source:
HPRD (in vitro, in vivo)

		GNA15	LTB4R
Gene Name		guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	leukotriene B4 receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Nucleotide Binding Leukotriene B4 Receptor Activity Leukotriene Receptor Activity
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway	Movement Of Cell Or Subcellular Component Muscle Contraction Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Leukotriene receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs
Diseases
GWAS		Heart failure ( 20445134)
Protein-Protein Interactions		19 interactors: ADRB2 ADRBK1 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	4 interactors: GNA15 GNAI2 GRK6 YWHAG
Entrez ID		2769	1241
HPRD ID		00760	03320
Ensembl ID		ENSG00000060558	ENSG00000213903
Uniprot IDs		P30679	Q15722
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Defense Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signaling Cell Communication Sensory Perception Of Pain Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Opioid Receptor Signaling Pathway Cellular Cation Homeostasis Cellular Response To Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Phosphorus Metabolic Process Cellular Chemical Homeostasis Blood Circulation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Muscle Contraction Response To Stress Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Cyclase Activity Immune Response Regulation Of Phosphorylation Cytosolic Calcium Ion Homeostasis Regulation Of MAPK Cascade Regulation Of Catalytic Activity Homeostatic Process Regulation Of Signaling Interleukin-8-mediated Signaling Pathway Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Muscle Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP Biosynthetic Process Negative Regulation Of Lyase Activity Response To Stimulus Regulation Of CAMP Metabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Catalytic Activity	G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Adenosine Receptor Signaling Pathway Signal Transduction Signaling Regulation Of Body Fluid Levels Cell Communication Negative Regulation Of Adenylate Cyclase Activity Wound Healing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Catalytic Activity Negative Regulation Of Lyase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Cell Activation Response To Wounding Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Nucleotide Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Mitochondrion Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Termination Of Signal Transduction Activation Of MAPKK Activity Regulation Of Cyclase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipase Activity G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling
Tagcloud ?			10d a2a adenosine adora1 adora2a adora3 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?			10d a2a adenosine adora1 adora2a adora3 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?