GNA11 and HTR2B

Number of citations of the paper that reports this interaction (PMID 11916537)
71

Data Source:
HPRD (in vivo)

		GNA11	HTR2B
Gene Name		guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Neuron Projection Synapse
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	G-protein Alpha-subunit Binding Serotonin Receptor Activity Ras GTPase Activator Activity Drug Binding Serotonin Binding
	Biological Process	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Heart Development Blood Coagulation Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G-protein Coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling Positive Regulation Of Ras GTPase Activity Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Embryonic Morphogenesis Positive Regulation Of Cytokine Secretion Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs			Eletriptan Methysergide Cabergoline Ropinirole Dihydroergotamine Pramipexole Triflupromazine Fenfluramine Lisuride Apomorphine Minaprine Tegaserod Doxepin Pergolide Bromocriptine Chlorprothixene Clomipramine 3,4-Methylenedioxymethamphetamine Asenapine
Diseases
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		17 interactors: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR	4 interactors: GNA11 GNAQ LNX1 SNTA1
Entrez ID		2767	3357
HPRD ID		00759	03077
Ensembl ID			ENSG00000135914
Uniprot IDs		P29992	P41595
PDB IDs			4IB4
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Vasoconstriction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Blood Circulation Cytosolic Calcium Ion Homeostasis Ion Homeostasis Chemical Homeostasis Regulation Of MAPK Cascade Regulation Of Phosphorylation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Homeostatic Process Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Phosphorylation Signal Transduction Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Cellular Chemical Homeostasis Signaling Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Cellular Metal Ion Homeostasis Cellular Homeostasis Cellular Cation Homeostasis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Ion Homeostasis Vascular Smooth Muscle Contraction Regulation Of Blood Pressure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Abiotic Stimulus Regulation Of Signal Transduction Muscle Contraction Regulation Of CAMP Biosynthetic Process Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Response To Stimulus Endothelin Receptor Signaling Pathway	Action Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Regulation Of Developmental Pigmentation Regulation Of Membrane Potential Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Neuron Remodeling Blood Coagulation Hemostasis Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To PH Maternal Behavior Heart Development Skeletal System Development Ventricular Cardiac Muscle Cell Action Potential Regulation Of Body Fluid Levels Wound Healing Regulation Of Membrane Repolarization Regulation Of Catenin Import Into Nucleus Cardiac Muscle Cell Action Potential Involved In Contraction Cell Activation Neuron Maturation Response To Wounding Regulation Of Sodium Ion Transmembrane Transport Response To PH Forebrain Neuron Development Cardiac Muscle Cell Action Potential Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cardiac Muscle Cell Contraction Cardiovascular System Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Neuromuscular Junction Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Vasoconstriction Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Regulation Of Sodium Ion Transport Embryonic Digit Morphogenesis
Tagcloud ?		amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?