GLUD1 and HPX

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GLUD1	HPX
Gene Name		glutamate dehydrogenase 1	hemopexin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding	Protein Binding Heme Transporter Activity Metal Ion Binding
	Biological Process	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Tricarboxylic Acid Metabolic Process	Positive Regulation Of Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Heme Transport Viral Process Hemoglobin Metabolic Process Heme Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives	Scavenging of heme from plasma
Drugs		L-Glutamic Acid NADH Hexachlorophene Nicotinamide-Adenine-Dinucleotide Adenosine-5\'-Diphosphate Guanosine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ASGR2 CRP DYNLL1 GOT2 HPX LSM1 NR4A1 ORM1 SEC62 STAT5A VTN	2 interactors: GLUD1 TP63
Entrez ID		2746	3263
HPRD ID		11748	00793
Ensembl ID		ENSG00000148672	ENSG00000110169
Uniprot IDs		B3KV55 E9KL48 P00367	P02790 Q9BS19
PDB IDs		1L1F 1NR1
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process 2-oxoglutarate Metabolic Process Regulation Of Immune Response Oxaloacetate Metabolic Process Transport Acute-phase Response Endocytosis Regulation Of Humoral Immune Response Positive Regulation Of Mast Cell Differentiation Receptor-mediated Endocytosis Acute Inflammatory Response Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Regulation Of Mast Cell Differentiation Fumarate Metabolic Process Development Of Secondary Male Sexual Characteristics Immune System Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Hormone-mediated Signaling Pathway Response To Ethanol Negative Regulation Of Mast Cell Apoptotic Process L-kynurenine Metabolic Process Creatinine Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Proliferation Positive Regulation Of Immune Response Glutamate Catabolic Process Isoleucine Metabolic Process Allantoin Metabolic Process Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Vesicle-mediated Transport Positive Regulation Of Innate Immune Response Taurine Metabolic Process Aspartate Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Posttranslational Protein Targeting To Membrane Negative Regulation Of Vasodilation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Erythrocyte Differentiation Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Prolactin Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation	Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Regulation Of Epidermal Cell Division Female Genitalia Morphogenesis Cloacal Septation Urinary Bladder Development Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Glutamate Catabolic Process Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Glutamate Biosynthetic Process Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Negative Regulation Of Epidermal Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Dicarboxylic Acid Catabolic Process Negative Regulation Of Cell Aging Keratinocyte Proliferation Establishment Of Skin Barrier Establishment Of Planar Polarity Epithelial Cell Differentiation Involved In Prostate Gland Development Genitalia Morphogenesis Regulation Of Water Loss Via Skin Post-anal Tail Morphogenesis Regulation Of Fibroblast Apoptotic Process Regulation Of Keratinocyte Proliferation Female Genitalia Development Sympathetic Nervous System Development Glutamate Metabolic Process Morphogenesis Of A Polarized Epithelium Regulation Of Cellular Senescence Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Notch Signaling Pathway Regulation Of Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Smooth Muscle Tissue Development Response To X-ray Hair Follicle Morphogenesis Morphogenesis Of An Epithelial Fold Negative Regulation Of Epithelial Cell Differentiation Glutamine Metabolic Process Substantia Nigra Development Prostate Gland Epithelium Morphogenesis
Tagcloud ?		alcoholics automatic brains caudate cortices dorsal epsilon excitatory executive gaba gamma1 glud2 glun2a glutamate ionotropic mortem movements mrnas outputs prominently putamen qpcr rho2 seeking striatal striatum thinking underlie voluntarily	acutely antral atresia autoradiography disconnection ewes externa follicles follicular folliculogenesis fsh gonadotropin gonadotropins granulosa greatest hpd hypophysectomy interna lh localize membrana nonspecific ovulation preantral stalk theca unless unresponsive unsuccessful
Tagcloud (Difference) ?		alcoholics automatic brains caudate cortices dorsal epsilon excitatory executive gaba gamma1 glud2 glun2a glutamate ionotropic mortem movements mrnas outputs prominently putamen qpcr rho2 seeking striatal striatum thinking underlie voluntarily	acutely antral atresia autoradiography disconnection ewes externa follicles follicular folliculogenesis fsh gonadotropin gonadotropins granulosa greatest hpd hypophysectomy interna lh localize membrana nonspecific ovulation preantral stalk theca unless unresponsive unsuccessful
Tagcloud (Intersection) ?