GLDC and TLR10

Number of citations of the paper that reports this interaction (PMID 16482509)
13

Data Source:
HPRD (two hybrid)

		GLDC	TLR10
Gene Name		glycine dehydrogenase (decarboxylating)	toll-like receptor 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Glycine Dehydrogenase (decarboxylating) Activity Electron Carrier Activity Lyase Activity Pyridoxal Phosphate Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Glycine Catabolic Process Oxidation-reduction Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Innate Immune Response Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Innate Immune System
Drugs		Pyridoxal Phosphate Glycine
Diseases
GWAS		Periodontal microbiota ( 22699663)	Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		1 interactors: TLR10	11 interactors: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2
Entrez ID		2731	81793
HPRD ID		01996	05884
Ensembl ID		ENSG00000178445	ENSG00000174123
Uniprot IDs		P23378	Q9BXR5
PDB IDs			2J67
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 10 Signaling Pathway Toll-like Receptor 5 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cytokine Secretion Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Protein Secretion Inflammatory Response Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Protein Transport Positive Regulation Of Immune Response Regulation Of Secretion Regulation Of Establishment Of Protein Localization	Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Response To Molecule Of Fungal Origin Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Innate Immune Response Detection Of Bacterial Lipoprotein MyD88-dependent Toll-like Receptor Signaling Pathway Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Bacterial Lipopeptide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Interleukin-6 Production Response To Peptidoglycan Detection Of Molecule Of Bacterial Origin Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Tumor Necrosis Factor Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Detection Of Bacterium Immune Response-regulating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Innate Immune Response Detection Of Biotic Stimulus Macrophage Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Glycine Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Platelet Aggregation Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Response To Fungus Immune Response Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Serine Family Amino Acid Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response
Tagcloud ?		asct2 caix classic follows gdh gls1 glut glutaminolysis glycine glycolysis hexokinase histologic idc ilc lobular manufactured mct4 metabolism negativity phgdh pleomorphic positivity psat1 psph sdha sdhb shmt1 stains tumoral	bewo broadly danger endosomal immunoassay initiating inter multiplex placental proper qpcr respond ten tlr2 tlr3 tlr4 tlr5 tlr6 tlr7 tlr8 tlr9 tlrs toll trimester trophoblast trophoblasts vegfa
Tagcloud (Difference) ?		asct2 caix classic follows gdh gls1 glut glutaminolysis glycine glycolysis hexokinase histologic idc ilc lobular manufactured mct4 metabolism negativity phgdh pleomorphic positivity psat1 psph sdha sdhb shmt1 stains tumoral	bewo broadly danger endosomal immunoassay initiating inter multiplex placental proper qpcr respond ten tlr2 tlr3 tlr4 tlr5 tlr6 tlr7 tlr8 tlr9 tlrs toll trimester trophoblast trophoblasts vegfa
Tagcloud (Intersection) ?