GFRA1 and TRADD

Number of citations of the paper that reports this interaction (PMID 15310755)
27

Data Source:
BioGRID (enzymatic study)

		GFRA1	TRADD
Gene Name		GDNF family receptor alpha 1	TNFRSF1A-associated via death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Death-inducing Signaling Complex Receptor Complex Membrane Raft
	Molecular Function	Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity	Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Protein Complex Binding Identical Protein Binding Binding, Bridging Death Domain Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Positive Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	Regulation by c-FLIP Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GDNF NCAM1 NRTN RET SOCS3 TRADD	24 interactors: BCL10 BIRC2 CNTRL DAPK1 FADD FAS GFRA1 HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		2674	8717
HPRD ID		03291	04610
Ensembl ID		ENSG00000151892
Uniprot IDs		B7Z856 P56159	B3KQZ9 Q15628
PDB IDs			1F2H 1F3V
Enriched GO Terms of Interacting Partners?		Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Ameboidal-type Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Stem Cell Development Positive Regulation Of Kidney Development Neuron Development Stem Cell Differentiation Autonomic Nervous System Development Anatomical Structure Morphogenesis Neuron Differentiation Axon Guidance Locomotion Signal Transduction Cytokine-mediated Signaling Pathway Morphogenesis Of An Epithelium Signaling Regulation Of Apoptotic Process Axonogenesis Cell Communication Movement Of Cell Or Subcellular Component Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Nerve Development Regulation Of Cell Death Generation Of Neurons Axon Development Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Zymogen Activation Metanephros Development Chemotaxis Neurogenesis Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ureteric Bud Development Neuron Projection Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Development Embryonic Morphogenesis Tissue Morphogenesis Interferon-gamma-mediated Signaling Pathway	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Tumor Necrosis Factor Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Peptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Endopeptidase Activity Cellular Response To Cytokine Stimulus Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Response To Cytokine Programmed Necrotic Cell Death Necrotic Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Organic Substance Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Necroptotic Signaling Pathway Zymogen Activation Negative Regulation Of Apoptotic Process Cellular Response To Organic Substance Signal Transduction Negative Regulation Of Programmed Cell Death Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Necroptotic Process Signaling Cellular Response To Mechanical Stimulus Cell Communication Response To Abiotic Stimulus
Tagcloud ?		amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Difference) ?		amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Intersection) ?