GFRA1 and RET

Number of citations of the paper that reports this interaction (PMID 10774729)
39

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GFRA1	RET
Gene Name		GDNF family receptor alpha 1	ret proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft
	Molecular Function	Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs			Imatinib
Diseases
GWAS			Hirschsprung's disease ( 19196962)
Protein-Protein Interactions		6 interactors: GDNF NCAM1 NRTN RET SOCS3 TRADD	36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3
Entrez ID		2674	5979
HPRD ID		03291	01266
Ensembl ID		ENSG00000151892	ENSG00000165731
Uniprot IDs		B7Z856 P56159	P07949 Q9BTX6
PDB IDs			1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Ameboidal-type Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Stem Cell Development Positive Regulation Of Kidney Development Neuron Development Stem Cell Differentiation Autonomic Nervous System Development Anatomical Structure Morphogenesis Neuron Differentiation Axon Guidance Locomotion Signal Transduction Cytokine-mediated Signaling Pathway Morphogenesis Of An Epithelium Signaling Regulation Of Apoptotic Process Axonogenesis Cell Communication Movement Of Cell Or Subcellular Component Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Nerve Development Regulation Of Cell Death Generation Of Neurons Axon Development Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Zymogen Activation Metanephros Development Chemotaxis Neurogenesis Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ureteric Bud Development Neuron Projection Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Development Embryonic Morphogenesis Tissue Morphogenesis Interferon-gamma-mediated Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Difference) ?		amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Intersection) ?