PYGO1 and BCL9

Number of citations of the paper that reports this interaction (PMID 11955446)
103

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PYGO1	BCL9
Gene Name		pygopus family PHD finger 1	B-cell CLL/lymphoma 9
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Golgi Apparatus Cis-Golgi Network
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Binding Beta-catenin Binding
	Biological Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Spermatid Nucleus Differentiation Post-embryonic Development Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS			Schizophrenia (negative symptoms) ( 23382809)
Protein-Protein Interactions		6 interactors: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1	3 interactors: CTNNB1 PYGO1 PYGO2
Entrez ID		26108	607
HPRD ID		06064	04000
Ensembl ID			ENSG00000116128
Uniprot IDs		A7Y2D6 Q9Y3Y4	O00512 Q1JQ81
PDB IDs		2VP7 2VPB 2VPD 2VPE 2VPG	2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9
Enriched GO Terms of Interacting Partners?		Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cartilage Development Canonical Wnt Signaling Pathway Histone H3-R17 Methylation Histone Methylation Stem Cell Maintenance Negative Regulation Of Mitotic Cell Cycle, Embryonic Myotube Differentiation Involved In Skeletal Muscle Regeneration Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Protein Methylation Regulation Of Organ Morphogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Intracellular Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Central Nervous System Vasculogenesis Trachea Formation Cellular Response To Indole-3-methanol Stem Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Common-partner SMAD Protein Phosphorylation Skeletal System Morphogenesis Wnt Signaling Pathway Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic SMAD Protein Import Into Nucleus Stem Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation	Germ Cell Development Wnt Signaling Pathway Kidney Development Regulation Of Histone H3-K4 Methylation Renal System Development Spermatid Nucleus Differentiation Urogenital System Development Regulation Of Histone Methylation Gamete Generation Developmental Process Involved In Reproduction Sexual Reproduction Multicellular Organismal Reproductive Process Canonical Wnt Signaling Pathway Multicellular Organism Reproduction Lens Development In Camera-type Eye Nucleus Organization Regulation Of Histone Modification Reproduction Spermatid Development Post-embryonic Development Spermatid Differentiation Single Organism Reproductive Process Reproductive Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Regulation Of Epithelial Cell Proliferation Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Cell Development Central Nervous System Vasculogenesis Trachea Formation Positive Regulation Of Chromatin Binding Cellular Response To Indole-3-methanol Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Camera-type Eye Development
Tagcloud ?		analyze bioinformatic bioinformatics category chemical coil contained formula heart helix highest homeodomain hydrophilic hydrophobicity hyrdrophilicity isoelectric physical plant point progress proline random regulate residues secondary structure theoretical tools transmembrane	anchor assistance benzimidazole benzothiazoles cleft crystallography discovered displaces docks emanating facilitating finger h3k4me hd1 interface ligandability methylated oncogenesis phd pocket privileged pygo reader relies scaffold surfaces tail template uncovers
Tagcloud (Difference) ?		analyze bioinformatic bioinformatics category chemical coil contained formula heart helix highest homeodomain hydrophilic hydrophobicity hyrdrophilicity isoelectric physical plant point progress proline random regulate residues secondary structure theoretical tools transmembrane	anchor assistance benzimidazole benzothiazoles cleft crystallography discovered displaces docks emanating facilitating finger h3k4me hd1 interface ligandability methylated oncogenesis phd pocket privileged pygo reader relies scaffold surfaces tail template uncovers
Tagcloud (Intersection) ?