BCL9

Gene Name		B-cell CLL/lymphoma 9
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cis-Golgi Network
	Molecular Function	Protein Binding Beta-catenin Binding
	Biological Process	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Schizophrenia (negative symptoms) ( 23382809)
Protein-protein Interactions		3 interactors: CTNNB1 PYGO1 PYGO2
Entrez ID		607
HPRD ID		04000
Ensembl ID		ENSG00000116128
Uniprot IDs		O00512 Q1JQ81
PDB IDs		2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9
Enriched GO Terms of Interacting Partners?		Germ Cell Development Wnt Signaling Pathway Kidney Development Regulation Of Histone H3-K4 Methylation Renal System Development Spermatid Nucleus Differentiation Urogenital System Development Regulation Of Histone Methylation Gamete Generation Developmental Process Involved In Reproduction Sexual Reproduction Multicellular Organismal Reproductive Process Canonical Wnt Signaling Pathway Multicellular Organism Reproduction Lens Development In Camera-type Eye Nucleus Organization Regulation Of Histone Modification Reproduction Spermatid Development Post-embryonic Development Spermatid Differentiation Single Organism Reproductive Process Reproductive Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Regulation Of Epithelial Cell Proliferation Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Cell Development Central Nervous System Vasculogenesis Trachea Formation Positive Regulation Of Chromatin Binding Cellular Response To Indole-3-methanol Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Camera-type Eye Development
Tagcloud ?		anchor assistance benzimidazole benzothiazoles cleft crystallography discovered displaces docks emanating facilitating finger h3k4me hd1 interface ligandability methylated oncogenesis phd pocket privileged pygo reader relies scaffold surfaces tail template uncovers