GAP43 and SPTAN1

Number of citations of the paper that reports this interaction (PMID 10521589)
6

Data Source:
HPRD (in vivo)

		GAP43	SPTAN1
Gene Name		growth associated protein 43	spectrin, alpha, non-erythrocytic 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Cell Junction Axon Filopodium Membrane Growth Cone Membrane	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Response To Wounding Glial Cell Differentiation Axon Choice Point Recognition Regulation Of Growth Tissue Regeneration Cell Fate Commitment Regulation Of Filopodium Assembly Axon Development	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways			Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Breast size ( 22747683)
Protein-Protein Interactions		8 interactors: CALM1 CSNK2A1 ELAVL4 PLCD1 PRKCB PRKCD RABEP1 SPTAN1	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		2596	6709
HPRD ID		01198	01684
Ensembl ID		ENSG00000172020	ENSG00000197694
Uniprot IDs		P17677 Q5U058	Q13813
PDB IDs			2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Dephosphorylation Platelet Activation Negative Regulation Of Insulin Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Dephosphorylation Inositol Phosphate Metabolic Process Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Actin Filament Polymerization Execution Phase Of Apoptosis Positive Regulation Of Phospholipase Activity Blood Coagulation Hemostasis Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Negative Regulation Of Protein Polymerization Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Phospholipid Catabolic Process Histone H3-T6 Phosphorylation Regulation Of Body Fluid Levels Regulation Of Dephosphorylation Wound Healing Negative Regulation Of Protein Complex Assembly Interleukin-10 Production Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Activation Cell Activation Response To Wounding Negative Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Filopodium Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Actin Filament Polymerization Interleukin-12 Production	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?			adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?			adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?