NCR3 and CD59

Number of citations of the paper that reports this interaction (PMID 14635045)
7

Data Source:
HPRD (in vitro, in vivo)

		NCR3	CD59
Gene Name		natural cytotoxicity triggering receptor 3	CD59 molecule, complement regulatory protein
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Vesicle Sarcolemma Compact Myelin Extracellular Vesicular Exosome
	Molecular Function		Complement Binding Protein Binding
	Biological Process	Inflammatory Response Immune Response Cell Recognition Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Cell Activation Negative Regulation Of Activation Of Membrane Attack Complex Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response
Pathways			Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Weight ( 19079260)
Protein-Protein Interactions		3 interactors: BAG6 CD247 CD59	12 interactors: C8A C9 CD2 CD8A CD9 EGFR GNAI3 NCR1 NCR3 SLC6A8 SMAD4 SRC
Entrez ID		259197	966
HPRD ID		11384	00117
Ensembl ID		ENSG00000204475
Uniprot IDs		O14931 Q05D23	E9PI80 P13987 Q6FHM9
PDB IDs		3NOI 3PV6	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of Protein Processing Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune System Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Lymphocyte Activation Regulation Of Protein Processing Protein Insertion Into ER Membrane Regulation Of Cell Activation Negative Regulation Of Complement Activation Regulation Of Cell Adhesion Protein Insertion Into Membrane Synaptonemal Complex Assembly Synaptonemal Complex Organization Regulation Of Defense Response To Virus By Virus Response To Stress Innate Immune Response Regulation Of Complement Activation Regulation Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Endoplasmic Reticulum Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Humoral Immune Response Synapsis Homologous Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Immune Response Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Defense Response Negative Regulation Of Cellular Protein Catabolic Process T Cell Costimulation Meiotic Chromosome Segregation Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Signal Transduction	Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Immune Response Defense Response Immune System Process Complement Activation, Alternative Pathway Positive Regulation Of Protein Transport Immune Response Membrane Organization Blood Coagulation Hemostasis Positive Regulation Of Immune System Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Cytolysis Single Organismal Cell-cell Adhesion Platelet Activation Regulation Of Complement Activation Regulation Of Body Fluid Levels Wound Healing Cell Adhesion Regulation Of Protein Transport Positive Regulation Of Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Establishment Of Protein Localization Leukocyte Mediated Immunity Adaptive Immune Response Response To Wounding Regulation Of Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transport Natural Killer Cell Activation Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Innate Immune Response Alkanesulfonate Metabolic Process Cytotoxic T Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Myeloid Dendritic Cell Activation Regulation Of Acute Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Positive Regulation Of Cytokine Secretion Regulation Of Protein Processing Positive Regulation Of Protein Import Into Nucleus Lymphocyte Activation
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3 txnrd1	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3 txnrd1	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Intersection) ?