NCR3 and CD247

Number of citations of the paper that reports this interaction (PMID 12731048)
15

Data Source:
HPRD (in vivo, in vitro)

		NCR3	CD247
Gene Name		natural cytotoxicity triggering receptor 3	CD247 molecule
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function		Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Inflammatory Response Immune Response Cell Recognition Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Weight ( 19079260)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		3 interactors: BAG6 CD247 CD59	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		259197	919
HPRD ID		11384	01729
Ensembl ID		ENSG00000204475	ENSG00000198821
Uniprot IDs		O14931 Q05D23	P20963
PDB IDs		3NOI 3PV6	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of Protein Processing Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune System Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Lymphocyte Activation Regulation Of Protein Processing Protein Insertion Into ER Membrane Regulation Of Cell Activation Negative Regulation Of Complement Activation Regulation Of Cell Adhesion Protein Insertion Into Membrane Synaptonemal Complex Assembly Synaptonemal Complex Organization Regulation Of Defense Response To Virus By Virus Response To Stress Innate Immune Response Regulation Of Complement Activation Regulation Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Endoplasmic Reticulum Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Humoral Immune Response Synapsis Homologous Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Immune Response Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Defense Response Negative Regulation Of Cellular Protein Catabolic Process T Cell Costimulation Meiotic Chromosome Segregation Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Signal Transduction	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3 txnrd1	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3 txnrd1	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?