FBXL2 and CCND2

Number of citations of the paper that reports this interaction (PMID 22323446)
12

Data Source:
BioGRID (enzymatic study)

		FBXL2	CCND2
Gene Name		F-box and leucine-rich repeat protein 2	cyclin D2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Protein Binding Protein Kinase Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Protein Phosphorylation Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division
Pathways			Cyclin D associated events in G1 G1 Phase Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Colorectal cancer ( 23266556 23263487) Major depressive disorder ( 19107115 23377640) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		7 interactors: AURKB CCND2 CDC34 COL7A1 PIK3R2 SKP1 UBE2D3	19 interactors: ABL1 AKAP8 CALM1 CALM2 CALM3 CDK4 CDK5 CDKN1A CDKN1B CDKN2A DMTF1 FBXL2 HIST1H1A NPDC1 PCGF2 PSMD10 RB1 RUNX1 SERTAD1
Entrez ID		25827	894
HPRD ID		05736	00451
Ensembl ID		ENSG00000153558	ENSG00000118971
Uniprot IDs		Q9UKC9	P30279
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Monoubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Protein Ubiquitination Proteolysis Response To Growth Factor Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Process Histone H3-S28 Phosphorylation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Polyubiquitination Spindle Stabilization Abscission Positive Regulation Of Inclusion Body Assembly Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Negative Regulation Of CAMP-mediated Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Cytokinesis Protein Localization To Kinetochore Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone-serine Phosphorylation Regulation Of Metabolic Process Histone Modification Regulation Of Inclusion Body Assembly Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Histone Monoubiquitination Cell Division	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Regulation Of Cellular Localization Positive Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Cell Cycle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Fc Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Arrest Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Organic Cyclic Compound Detection Of Calcium Ion
Tagcloud ?		abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c rabgef1 sh3kbp1 snp snx8 synj1 xpo1 xrn1	associations blotting ccnd1 dab2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c rabgef1 sh3kbp1 snp snx8 synj1 xpo1 xrn1	associations blotting ccnd1 dab2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?