FBXL2 and COL7A1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FBXL2	COL7A1
Gene Name		F-box and leucine-rich repeat protein 2	collagen, type VII, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways			Collagen formation Laminin interactions Collagen degradation Anchoring fibril formation Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AURKB CCND2 CDC34 COL7A1 PIK3R2 SKP1 UBE2D3	14 interactors: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MMP2 SHKBP1 THBS1 ZC3H7A
Entrez ID		25827	1294
HPRD ID		05736	00358
Ensembl ID		ENSG00000153558	ENSG00000114270
Uniprot IDs		Q9UKC9	Q02388 Q59F16
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Monoubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Protein Ubiquitination Proteolysis Response To Growth Factor Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Process Histone H3-S28 Phosphorylation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Polyubiquitination Spindle Stabilization Abscission Positive Regulation Of Inclusion Body Assembly Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Negative Regulation Of CAMP-mediated Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Cytokinesis Protein Localization To Kinetochore Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone-serine Phosphorylation Regulation Of Metabolic Process Histone Modification Regulation Of Inclusion Body Assembly Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Histone Monoubiquitination Cell Division	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Blood Vessel Development Vasculature Development Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Blood Vessel Morphogenesis Locomotion Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Endodermal Cell Differentiation Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Retinal Blood Vessel Morphogenesis Cell Junction Assembly Endoderm Formation Cellular Response To Amino Acid Stimulus Developmental Process Collagen Catabolic Process Organ Morphogenesis Intramembranous Ossification Collagen Metabolic Process Cell Morphogenesis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Skeletal System Morphogenesis Bone Trabecula Formation Endoderm Development Multicellular Organismal Metabolic Process Multicellular Organismal Development Cell Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Hemidesmosome Assembly Response To Amino Acid Bone Trabecula Morphogenesis Axon Guidance Formation Of Primary Germ Layer System Development Cell Projection Morphogenesis Cell Part Morphogenesis Retina Vasculature Development In Camera-type Eye Morphogenesis Of A Polarized Epithelium Cellular Response To Acid Chemical Branching Involved In Salivary Gland Morphogenesis Gastrulation Platelet Activation
Tagcloud ?		abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c rabgef1 sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?		abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c rabgef1 sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?