ICMT and RAC2

Number of citations of the paper that reports this interaction (PMID 9614111)
72

Data Source:
HPRD (in vitro)

		ICMT	RAC2
Gene Name		isoprenylcysteine carboxyl methyltransferase	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nuclear Envelope Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity CAMP Response Element Binding Protein Binding	GTPase Activity GTP Binding
	Biological Process	In Utero Embryonic Development Liver Development Cellular Protein Modification Process C-terminal Protein Methylation Protein Targeting To Membrane Positive Regulation Of Cell Proliferation Multicellular Organism Growth Regulation Of Ras Protein Signal Transduction Regulation Of Nucleic Acid-templated Transcription	Actin Filament Organization Signal Transduction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Platelet Activation Bone Resorption Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration
Pathways			Signaling by GPCR Axon guidance Semaphorin interactions Signaling by Wnt beta-catenin independent WNT signaling Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation PCP/CE pathway Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Graves' disease ( 23612905) Longevity ( 20834067)
Protein-Protein Interactions		4 interactors: HRAS RAC1 RAC2 RHOA	20 interactors: ACTB ADAM22 AFG3L2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		23463	5880
HPRD ID		09321	03628
Ensembl ID		ENSG00000116237	ENSG00000128340
Uniprot IDs		O60725	P15153
PDB IDs			1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Axon Guidance Blood Coagulation Hemostasis Regulation Of Cell Projection Organization Axonogenesis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Wound Healing Actin Cytoskeleton Organization Regulation Of Cell Projection Assembly Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Actin Filament-based Process Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Neuron Projection Development Positive Regulation Of Lamellipodium Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Platelet Activation Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Morphogenesis Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Positive Regulation Of Granulocyte Chemotaxis Regulation Of Neutrophil Chemotaxis Locomotion Regulation Of Neutrophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Developmental Process Multicellular Organismal Development Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurogenesis Signal Transduction Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Response To External Stimulus Superoxide Metabolic Process Signaling Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Communication Anatomical Structure Development Response To Stimulus System Development Cell Differentiation Positive Regulation Of Metabolic Process Generation Of Neurons Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Regulation Of Cell Morphogenesis Innate Immune Response Midbrain Development SMAD Protein Complex Assembly Cellular Response To Stimulus Axonogenesis Defense Response Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Reactive Oxygen Species Metabolic Process Regulation Of Cell Adhesion Neuron Projection Morphogenesis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Defense Response To Virus By Virus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Localization Cell Development
Tagcloud ?		amoeba caenorhabditis colonize colonized colonizes cultivated cyst dot dota evade excreted governed hosts invade legionella legionnaires metazoan nematode nematodes persistence pneumophila protozoa protozoan replicated subvert tracts ultrastructural worm	aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Difference) ?		amoeba colonize colonized colonizes cultivated cyst dot dota evade excreted governed hosts invade legionella legionnaires metazoan nematode nematodes persistence pneumophila protozoa protozoan replicated subvert tracts ultrastructural worm	aldrich basket ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Intersection) ?		caenorhabditis