NCSTN and BACE1

Number of citations of the paper that reports this interaction (PMID 12054507)
5

Data Source:
HPRD (in vitro, in vivo)

		NCSTN	BACE1
Gene Name		nicastrin	beta-site APP-cleaving enzyme 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Integral Component Of Membrane Melanosome Extracellular Vesicular Exosome	Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Axon Cytoplasmic Vesicle Membrane
	Molecular Function	Endopeptidase Activity Protein Binding	Beta-amyloid Binding Aspartic-type Endopeptidase Activity Protein Binding Beta-aspartyl-peptidase Activity Enzyme Binding
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Membrane Protein Intracellular Domain Proteolysis T Cell Proliferation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Beta-amyloid Metabolic Process Epithelial Cell Proliferation Apoptotic Signaling Pathway	Proteolysis Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Degradation of the extracellular matrix Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs			MMI-175 N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide 4-(4-FLUOROBENZYL)PIPERIDINE N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE 6-[2-(3\'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE N~3~-BENZYLPYRIDINE-2,3-DIAMINE N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE 4-(2-aminoethyl)-2-cyclohexylphenol 4-(2-aminoethyl)-2-ethylphenol 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine (6R)-2-amino-6-[2-(3\'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (6S)-2-amino-6-(3\'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
Diseases
GWAS			Cardiovascular disease risk factors ( 21779381)
Protein-Protein Interactions		10 interactors: ABL1 APH1A APH1B APP BACE1 PSEN1 PSEN2 PSENEN SPP1 TMED10	22 interactors: APP ATP1B1 BRI3 CMPK1 CSNK1D FBXO2 FURIN GGA1 GGA2 GGA3 ITM2C KHSRP LRP1 MMP2 NCSTN PCSK9 PDIA3 PLSCR1 PSAP PSEN1 RANBP9 SELPLG
Entrez ID		23385	23621
HPRD ID		05584	07255
Ensembl ID		ENSG00000162736	ENSG00000186318
Uniprot IDs		F6Y097 Q92542	B7Z3K2 B7Z3Z4 P56817 Q5W9H2
PDB IDs			1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2F3E 2F3F 2FDP 2G94 2HIZ 2HM1 2IQG 2IRZ 2IS0 2NTR 2OAH 2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU 2P4J 2P83 2P8H 2PH6 2PH8 2Q11 2Q15 2QK5 2QMD 2QMF 2QMG 2QP8 2QU2 2QU3 2QZK 2QZL 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4 2WJO 2XFI 2XFJ 2XFK 2ZDZ 2ZE1 2ZHR 2ZHS 2ZHT 2ZHU 2ZHV 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJL 2ZJM 2ZJN 3BRA 3BUF 3BUG 3BUH 3CIB 3CIC 3CID 3CKP 3CKR 3DM6 3DUY 3DV1 3DV5 3EXO 3FKT 3H0B 3HVG 3HW1 3I25 3IGB 3IN3 3IN4 3IND 3INE 3INF 3INH 3IVH 3IVI 3IXJ 3IXK 3K5C 3K5D 3K5F 3K5G 3KMX 3KMY 3KN0 3KYR 3L38 3L3A 3L58 3L59 3L5B 3L5C 3L5D 3L5E 3L5F 3LHG 3LNK 3LPI 3LPJ 3LPK 3MSJ 3MSK 3MSL 3N4L 3NSH 3OHF 3OHH 3OOZ 3PI5 3QBH 3QI1 3R1G 3R2F 3RSV 3RSX 3RTH 3RTM 3RTN 3RU1 3RVI 3S2O 3S7L 3S7M 3SKF 3SKG 3TPJ 3TPL 3TPP 3TPR 3U6A 3UDH 3UDJ 3UDK 3UDM 3UDN 3UDP 3UDQ 3UDR 3UDY 3UFL 3UQP 3UQR 3UQU 3UQW 3UQX 3VEU 3VF3 3VG1 3VV6 3VV7 3VV8 3WB4 3WB5 3ZMG 3ZOV 4ACU 4ACX 4AZY 4B00 4B05 4B0Q 4B1C 4B1D 4B1E 4B70 4B72 4B77 4B78 4BEK 4BFD 4D83 4D85 4D88 4D89 4D8C 4DH6 4DI2 4DJU 4DJV 4DJW 4DJX 4DJY 4DPF 4DPI 4DUS 4DV9 4DVF 4EWO 4EXG 4FCO 4FGX 4FM7 4FM8 4FRI 4FRJ 4FRK 4FRS 4FS4 4FSE 4FSL 4GID 4GMI 4H1E 4H3F 4H3G 4H3I 4H3J 4HA5 4HZT 4I0E 4I0F 4I0G 4I0H 4I0J 4I0Z 4I10 4I11 4I12 4I1C 4J0T 4J0V 4J0Y 4J0Z 4J17 4J1C 4J1E 4J1F 4J1H 4J1I 4J1K 4JOO 4JP9 4JPC 4JPE 4K8S 4K9H 4KE0 4KE1 4L7G 4L7H 4L7J 4LC7 4LXA 4LXK 4LXM
Enriched GO Terms of Interacting Partners?		Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Intracellular Domain Proteolysis Chemotaxis Locomotion Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Neuron Development Apoptotic Process Protein Processing Neurogenesis Axonogenesis Programmed Cell Death Beta-amyloid Metabolic Process Cell Death Death Axon Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Response To External Stimulus Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Death Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Morphogenesis Involved In Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Nervous System Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Thymus Development Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting System Development Regulation Of Protein Tyrosine Kinase Activity Cell Morphogenesis Cell Development Neurotrophin Signaling Pathway Cell Projection Organization	Neuron Differentiation Establishment Of Localization In Cell Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Extracellular Matrix Disassembly Protein Processing Transport Cellular Localization Intracellular Transport Generation Of Neurons Positive Regulation Of Proteolysis Notch Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Neurogenesis Regulation Of Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Protein Transport Vesicle-mediated Transport Amyloid Precursor Protein Catabolic Process Cell Activation Establishment Of Protein Localization Negative Regulation Of Neuron Differentiation Regulation Of Apoptotic Process Regulation Of Signaling Blood Coagulation Hemostasis Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Locomotion Amyloid Precursor Protein Metabolic Process Nervous System Development Intracellular Protein Transport Negative Regulation Of Neurogenesis Response To External Stimulus Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Notch Receptor Processing Regulation Of Body Fluid Levels Regulation Of Receptor Activity Cholesterol Metabolic Process Neuron Development Negative Regulation Of Neuron Projection Development
Tagcloud ?		achieve apoe bace1 classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 psen2 stages tangles tau trees	abca1 administrated amplitudes aspartic bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave
Tagcloud (Difference) ?		achieve apoe classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 psen2 stages tangles tau trees	abca1 administrated amplitudes aspartic bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave
Tagcloud (Intersection) ?		bace1