NCSTN and TMED10

Number of citations of the paper that reports this interaction (PMID 16641999)
75

Data Source:
HPRD (in vivo)

		NCSTN	TMED10
Gene Name		nicastrin	transmembrane emp24-like trafficking protein 10 (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Integral Component Of Membrane Melanosome Extracellular Vesicular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane Integral Component Of Membrane COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Extracellular Vesicular Exosome Gamma-secretase Complex
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Syntaxin Binding Protein Complex Binding
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Membrane Protein Intracellular Domain Proteolysis T Cell Proliferation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Beta-amyloid Metabolic Process Epithelial Cell Proliferation Apoptotic Signaling Pathway	Kidney Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Organization Cargo Loading Into Vesicle COPI-coated Vesicle Budding Response To Alkaloid Regulated Secretory Pathway Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Protein Oligomerization Regulation Of Beta-amyloid Formation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Degradation of the extracellular matrix Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS			Height ( 19343178)
Protein-Protein Interactions		10 interactors: ABL1 APH1A APH1B APP BACE1 PSEN1 PSEN2 PSENEN SPP1 TMED10	15 interactors: APH1A ARCN1 ARF1 COPA COPB1 COPB2 COPE COPG1 COPZ1 DHODH GORASP2 NCSTN PSENEN SEC23B TMED2
Entrez ID		23385	10972
HPRD ID		05584	12013
Ensembl ID		ENSG00000162736	ENSG00000170348
Uniprot IDs		F6Y097 Q92542	B4DL12 P49755
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Intracellular Domain Proteolysis Chemotaxis Locomotion Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Neuron Development Apoptotic Process Protein Processing Neurogenesis Axonogenesis Programmed Cell Death Beta-amyloid Metabolic Process Cell Death Death Axon Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Response To External Stimulus Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Death Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Morphogenesis Involved In Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Nervous System Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Thymus Development Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting System Development Regulation Of Protein Tyrosine Kinase Activity Cell Morphogenesis Cell Development Neurotrophin Signaling Pathway Cell Projection Organization	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Membrane Budding Golgi Vesicle Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Transport Protein Localization Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Amyloid Precursor Protein Catabolic Process Membrane Protein Intracellular Domain Proteolysis Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Cellular Localization Notch Receptor Processing Cellular Protein Localization Membrane Protein Proteolysis Organelle Organization Transport Ephrin Receptor Signaling Pathway ER To Golgi Vesicle-mediated Transport Notch Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cerebellar Purkinje Cell Layer Maturation Apoptotic Signaling Pathway Axon Guidance Cerebellum Maturation 'de Novo' UMP Biosynthetic Process Body Fluid Secretion Axonogenesis Establishment Of Golgi Localization
Tagcloud ?		achieve apoe bace1 classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 psen2 stages tangles tau trees	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Difference) ?		achieve apoe bace1 classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 psen2 stages tangles tau trees	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Intersection) ?