SCFD1 and PPBP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SCFD1	PPBP
Gene Name		sec1 family domain containing 1	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi-associated Vesicle Cis-Golgi Network Plasma Membrane Golgi Transport Complex SNARE Complex Golgi Cisterna Membrane	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Syntaxin Binding Protein N-terminus Binding	Glucose Transmembrane Transporter Activity Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Retrograde Vesicle-mediated Transport, Golgi To ER Post-Golgi Vesicle-mediated Transport Vesicle Docking Involved In Exocytosis Phagocytosis Response To Toxic Substance Protein Transport Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Autophagic Vacuole Assembly	Leukocyte Migration Involved In Inflammatory Response Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Glucose Transport Platelet Activation Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Positive Regulation Of Cell Division Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs			Ethanesulfonic Acid
Diseases
GWAS			Metabolite levels ( 22916037)
Protein-Protein Interactions		5 interactors: DLST PPBP STX5 USO1 USP22	21 interactors: CELF1 CMTM6 COPG1 COPS7A COX17 CSNK2A1 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		23256	5473
HPRD ID		10210	07171
Ensembl ID		ENSG00000092108
Uniprot IDs		Q8WVM8	P02775
PDB IDs			1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?		Vesicle Fusion With Golgi Apparatus Vesicle Fusion Organelle Fusion Vesicle Docking Membrane Docking ER To Golgi Vesicle-mediated Transport Membrane Fusion Golgi Vesicle Docking Golgi Disassembly L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Vesicle Organization Golgi Vesicle Transport Golgi Inheritance Regulation Of Golgi Organization Lysine Catabolic Process Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Protein Catabolic Process Transcytosis Leukocyte Migration Involved In Inflammatory Response Histone Deubiquitination Acetyl-CoA Metabolic Process Establishment Of Localization In Cell Hexose Transmembrane Transport Histone Ubiquitination Cytoplasmic Transport Organelle Disassembly	Interleukin-8-mediated Signaling Pathway Chemotaxis Response To External Stimulus Dendritic Cell Chemotaxis Dendritic Cell Migration Locomotion Cell Chemotaxis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Receptor Internalization Movement Of Cell Or Subcellular Component Vesicle Docking Involved In Exocytosis Negative Regulation Of Neutrophil Apoptotic Process Basolateral Protein Localization Chemokine-mediated Signaling Pathway Golgi Vesicle Transport Vesicle Docking Neutrophil Mediated Killing Of Gram-positive Bacterium Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Membrane Docking Post-Golgi Vesicle-mediated Transport Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Defense Response Leukocyte Chemotaxis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endopeptidase Activity Cell Migration Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Membrane Organization Regulation Of Peptidase Activity Vesicle-mediated Transport Immune System Process Negative Regulation Of Mitochondrial Membrane Potential Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Cell Motility Regulation Of Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Intracellular Transport Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Mitral Valve Development
Tagcloud ?			10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Difference) ?			10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Intersection) ?